prudect name : AG-490 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, AG-490 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, AG-490 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that AG-490 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by AG-490 leads to lower levels of p85 phosphorylation and p-13 kinase activation. AG-490 is an inhibitor of JAK3.
AG-490

Synonyms: CAS NO: 134036-52-5Molecular Formula: C₁₇H₁₄N₂O₃Molecular Weight: 294.30Purity: 98% minSolubility: In DMSOStorage: -20°C

1221186-53-3 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18496697

prudect name : AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8¦ÌM for EGFR and JAK, respectively. It inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo. It selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal hematopoiesis. It inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of MF tumor cells. It displays apoptotic and antiproliferative properties with IC50 of 1.7, 2.8 and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively.
AG 490

Synonyms: CAS NO: 133550-30-8Molecular Formula: C₁₇H₁₄N₂O₃Molecular Weight: 294.3Purity: 98% minSolubility: In DMSOStorage: -20°C

364782-34-3 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502931