prudect name : ICG-001 is a selective Wnt/¦Â-catenin signalling inhibitor with an IC50 of 3¦ÌM. After selectively binding of ICG-001 to the NH2 terminus of cyclic AMP response element binding protein (CREB), ICG-001 prevented beta-catenin/TCF signaling. ICG-001 elevated the activities of caspase in colon carcinoma cell lines, but not normal cells via down regulation of survivin. It is exhibited that ICG-001 rescues defects in neuronal differentiation and reverse pulmonary fibrosis. ICG-001 also suppressed the interaction between CREB and ¦Ã-catenin.
ICG-001

Synonyms: BCP000786CAS NO: 780757-88-2Molecular Formula: C₃₃H₃₂N₄O₄Molecular Weight: 548.63Purity: 98% minSolubility: In DMSOStorage: −20°C

CP 690550 citrate References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519927

prudect name : ICG-001 has no effect on the related reporter construct, FOPFLASH, which contains mutated TCF sites. After treatment with 25¦ÌM of ICG-001 for 8 hours, SW480 cell reduces the steady-state levels of Survivin and Cyclin D1 RNA and protein, both of which can be up-regulated by ¦Â-catenin. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells. ICG-001, can phenotypically rescue normal nerve growth factor (NGF) -induced neuronal differentiation and neurite outgrowth in the presenilin-1 mutant cells, emphasizing the importance of the TCF/¦Â-catenin signaling pathway on neurite outgrowth and neuronal differentiation. A recent study demonstrates that 5¦ÌM ICG-001 inhibits leptin-induced EMT, invasion and tumorsphere formation in MCF7 cells.
ICG-001

Synonyms: CAS NO: 847591-62-2Molecular Formula: C₃₃H₃₂N₄O₄Molecular Weight: 548.63Purity: 98% minSolubility: In DMSOStorage: -20°C

TL-32711 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18520326