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CAL-101 intermediates N-2

June 21, 2017

prudect name : CAL-101 intermediates N-2CAL-101 intermediates N-2 Synonyms: CAS NO: 870281-85-9Molecular Formula: Molecular Weight: Purity: 98% minSolubility: Storage: -20oC SYN-115 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18509173

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Biological Activity of CYC116: CYC116 is an orally bioavailable£¬small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC116 inhibits Aurora kinases A and B and VEGFR2, resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. CYC116 has a unique target profile involving both cell cycle and angiogenesis inhibition mechanisms. In preclinical studies, it demonstrated antitumor activity in both solid tumors and hematological cancers.

prudect name : Biological Activity of CYC116: CYC116 is an orally bioavailable£¬small molecule Aurora kinase/VEGFR2 inhibitor with antineoplastic activity. CYC116 inhibits Aurora kinases A and B and VEGFR2, resulting in…

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prudect name : Cefoxitin sodiumSynonyms: CAS NO: 33564-30-6Molecular Formula: C16H16N3NaO7S2Molecular Weight: 449.43Purity: 98% minSolubility: Storage:

prudect name : Cefoxitin sodium Synonyms: CAS NO: 33564-30-6Molecular Formula: C16H16N3NaO7S2Molecular Weight: 449.43Purity: 98% minSolubility: Storage: −20°C MK-8931 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18509045

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prudect name : CTX 0294885;CTX0294885Synonyms: CTX-0294885CAS NO: 1439934-41-4Molecular Formula: C22H24ClN7OMolecular Weight: 437.17Purity: 98% minSolubility: in

prudect name : CTX 0294885;CTX0294885 Synonyms: CTX-0294885CAS NO: 1439934-41-4Molecular Formula: C22H24ClN7OMolecular Weight: 437.17Purity: 98% minSolubility: in DMSOStorage: -20oC ABT-267 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508996

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CX-4945 (CX 4945) is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2¦Á, respectively. CX-4945 (CX 4945) has broad spectrum anti-proliferative activity in multiple cancer cell lines. The antiproliferative activity of CX-4945 (CX 4945) against cancer cells correlated with expression levels of the CK2¦Á catalytic subunit. Attenuation of PI3K/Akt signaling by CX-4945 (CX 4945; Silmitasertib) was evidenced by dephosphorylation of Akt on the CK2-specific S129 site and the canonical S473 and T308 regulatory sites. CX-4945 (CX 4945) suppresses Akt signaling and inhibits proliferation of HUVEC Cells. CX-4945 (CX 4945) caused cell-cycle arrest and selectively induced apoptosis in cancer cells relative to normal cells. In models of angiogenesis, CX-4945 (CX 4945) inhibited human umbilical vein endothelial cell migration, tube formation, and blocked CK2-dependent hypoxia-induced factor 1 alpha (HIF-1¦Á) transcription in cancer cells. Collectively, CX-4945 (CX 4945) inhibits pro-angiogenic CK2 signaling in vitro and in vivo

prudect name : CX-4945 (CX 4945) is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for…

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CCT128930 is a novel potent ATP-competitive, AKT inhibitor with an IC50 of 6 nM. CCT128930 prevents AKT activity in vitro and in vivo and induces marked antitumor responses. CCT128930 showed significantly antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. CCT128930 caused a G1 arrest in PTEN-null U87MG human glioblastoma cells, in good agreement with AKT pathway blockade

prudect name : CCT128930 is a novel potent ATP-competitive, AKT inhibitor with an IC50 of 6 nM. CCT128930 prevents AKT activity in vitro and in vivo and induces marked antitumor…

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For the treatment of adults with high cholesterol and endogenous hypertriglyceridemia

prudect name : For the treatment of adults with high cholesterol and endogenous hypertriglyceridemiaCiprofibrate Synonyms: CAS NO: 52214-84-3Molecular Formula: C13H14Cl2O3Molecular Weight: 289.16Purity: 99%Solubility: Storage: -20¡æ CP 673451 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508964

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Cilomilast(SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ¡Ö100 nM). Cilomilast(SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ¡Ö100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast(SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast(SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.

prudect name : Cilomilast(SB-207499) is among the first of a new generation of PDE4 inhibitors (Ki ¡Ö100 nM). Cilomilast(SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ¡Ö100…

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CGK733 is able to confer robust growth to senescent cells that have ceased proliferation. Senescence-associated ¦Â-galactosidase (SA¨C¦Â-gal) activity disappears in CGK733-treated cells. CGK733 shows greater potency in inhibiting ATM/ATR than LY294002 (IC50 , ~5 ¦ÌM for ATM and ATR), a pan-inhibitor of PI3K and PIKKs. CGK733 (30 ¦ÌM) treated for 24h causes ~60% cell death in senescent MCF-7 cells. CGK733 (20 ¦ÌM) induces the loss of cyclin D1 via the ubiquitin- dependent proteasomal degradation pathway in MCF-7 and T47D breast cancer cell lines. CGK733 at concentrations ranging from 0.6- 40 ¦ÌM, inhibits proliferation of MCF-7 and T47D estrogen receptor (ER) positive breast cancer cells, MDA-MB436 ER negative breast cancer cells, LnCap pros-tate cancer cells and HCT116 colon cancer cells. Furthermore, CGK733 also suppresses proliferation of non- transformed mouse BALB/c 3T3 embryonic fibroblast cells. The CGK733-mediated inhibition of proliferation is dose dependent and significant at doses as low as 2.5 ¦ÌM.

prudect name : CGK733 is able to confer robust growth to senescent cells that have ceased proliferation. Senescence-associated ¦Â-galactosidase (SA¨C¦Â-gal) activity disappears in CGK733-treated cells. CGK733 shows greater potency in…

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prudect name : CatharanthineSynonyms: CAS NO: 2468-21-5Molecular Formula: C21H24N2O2Molecular Weight: 336.43Purity: 99%Solubility: Storage: −20°C

prudect name : Catharanthine Synonyms: CAS NO: 2468-21-5Molecular Formula: C21H24N2O2Molecular Weight: 336.43Purity: 99%Solubility: Storage: −20°C 2 years Cy5 NHS Ester References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508872

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