CHIR-99021(CT99021) is a glycogen synthase kinase 3¦Â (GSK3¦Â) inhibitor that has antiproliferative activity in vitro and in vivo. [1] CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10¦ÌM. [1] CHIR-99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) with 350-fold selectivity toward GSK-3¦Â compared to CDKs

 June 21, 2017

prudect name : CHIR-99021(CT99021) is a glycogen synthase kinase 3¦Â (GSK3¦Â) inhibitor that has antiproliferative activity in vitro and in vivo. [1] CHIR-99021 inhibits GSK-3 with IC50 at 7 nM….

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CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively. CUDC-101 has novel structure incorporating HDAC inhibitory functionality into the pharmacophore of the EGFR and HER2 inhibitors. In most tumor cell lines tested, CUDC-101 exhibits efficient antiproliferative activity with greater potency than vorinostat (SAHA), erlotinib, lapatinib, and combinations of vorinostat/erlotinib and vorinostat/lapatinib. In vivo, CUDC-101 promotes tumor regression or inhibition in various cancer xenograft models including nonsmall cell lung cancer (NSCLC), liver, breast, head and neck, colon, and pancreatic cancers.

prudect name : CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively. CUDC-101 has novel structure incorporating HDAC inhibitory functionality…

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Calcitriol, also called 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3, is the hormonally active form of vitamin D with three hydroxyl groups (abbreviated 1,25-(OH)2D3 or simply 1,25(OH)2D). It increases the level of calcium (Ca2+) in the blood by increasing the uptake of calcium from the gut into the blood, decreasing the transfer of calcium from blood to the urine by the kidney, and increasing the release of calcium into the blood from bone.

prudect name : Calcitriol, also called 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3, is the hormonally active form of vitamin D with three hydroxyl groups (abbreviated 1,25-(OH)2D3 or simply 1,25(OH)2D). It increases the…

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prudect name : Coenzyme Q10;Ubiquinone 10;UbidecarenoneSynonyms: CAS NO: 303-98-0Molecular Formula: C59H90O4Molecular Weight: 863.36Purity: 99% minSolubility:

prudect name : Coenzyme Q10;Ubiquinone 10;Ubidecarenone Synonyms: CAS NO: 303-98-0Molecular Formula: C59H90O4Molecular Weight: 863.36Purity: 99% minSolubility: in DMSOStorage: -20oC AZD8055 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508818

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CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. Although the exact mechanism of action is unknown, alpha-lipoic acid analogue CPI-613 has been shown to inhibit metabolic and regulatory processes required for cell growth in solid tumors. Both enantiomers in the racemic mixture exhibit antineoplastic activity.

prudect name : CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. Although the exact mechanism of action…

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Cidofovir(Vistide) is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis. (IC50= 0.94 ¦ÌM) A wild type HCMV laboratory strain (AD 169) and 3 ganciclovir-resistant clinical isolates(generated as a result of Ganciclovir therapy) that are cross-resistant to cidofovir were also included in the cidofovir susceptibility assays. AD 169 showed a cidofovir IC50 value of 0.6 pM, and the ganciclovir- resistant isolates showed cidofovir IC50 values ranging from 2.3 to 16 pM

prudect name : Cidofovir(Vistide) is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis. (IC50= 0.94 ¦ÌM) A wild type HCMV laboratory strain (AD 169) and 3 ganciclovir-resistant…

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Clemizole is an H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B¡¯s RNA binding and hepatitis C virus (HCV) replication.

prudect name : Clemizole is an H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B¡¯s RNA binding and hepatitis C virus (HCV) replication.Clemizole Synonyms: CAS…

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prudect name : CeftezoleSynonyms: CAS NO: 26973-24-0Molecular Formula: C13H12N8O4S3Molecular Weight: 440.48Purity: 98% minSolubility: Storage: −20°C

prudect name : Ceftezole Synonyms: CAS NO: 26973-24-0Molecular Formula: C13H12N8O4S3Molecular Weight: 440.48Purity: 98% minSolubility: Storage: −20°C EGF-816 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508782

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prudect name : Carboprost tromethamineSynonyms: CAS NO: 58551-69-2Molecular Formula: C21H36O5.C4H11NO3Molecular Weight: 489.64Purity: 99%Solubility: Storage: -20¡æ

prudect name : Carboprost tromethamine Synonyms: CAS NO: 58551-69-2Molecular Formula: C21H36O5.C4H11NO3Molecular Weight: 489.64Purity: 99%Solubility: Storage: -20¡æ XCT 790 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18508759

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CX-6258 is a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. CX-6258 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models. Inhibition of Pim kinases is expected to have a beneficial effect as cancer therapy.

prudect name : CX-6258 is a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. CX-6258 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two…

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