Ed that the polymorphic variant may increase the risk

May 18, 2018

Ed that the polymorphic variant may increase the risk Ed that the polymorphic variant may increase the risk PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28461585 only among Africans [42]. However, the meta-analysis has not considered histopathological type of breast cancer and it is likely that since there are different risk factors for ductal andJablonska et al. BMC Cancer (2015) 15:Page 10 ofnon-ductal breast cancer, the effects of SNPs may also vary considerably [43]. Notably, the significant association for GPX1 polymorphism in the mentioned study by Meplan et al., has been restricted only to the non-ductal cancers [38]. Nevertheless, we did not expect to find significant odds ratios in this study (it was not the main aim of the study) due to the small sample size, and there is a high probability that the observed effect of GPX1 polymorphism could occur by chance. However, it has been the first such a study regarding sporadic breast cancer risk and GPX1 polymorphism conducted among Polish women, and considering the fact that similar protective effect of GPX1 Leu variant has been found in Polish population also in the case of lung and laryngeal cancers [44], the presented results deserve further investigation. For other investigated SNPs: rs713041 (GPX4), rs3877899 (SEPP1), rs5859 (SEP15) and rs4880 (SOD2), we failed to find any associations with the breast cancer risk. Similarly, we did not observe any significant genegene interactions of potential interest as suggested by other studies, including GPX1 x SOD2 and GPX1 x SEPP1 [8, 38].Breast cancer risk and Se statussame confounders to both groups (cancer cases and control subjects) and cannot rule out that the observed associations were not influenced by potential confounding factors, not controlled for in the study (as for example diet or supplements use). Nevertheless, both groups were residents of the same area, and were not different in terms of age, BMI, smoking status and menopausal status. It should be also appreciated that all the subjects enrolled in the control group had negative screening order GS-9620 mammograms and this information was crucial in the assessment of biochemical processes linked to breast cancer. Another weakness of the study concerns relatively small sample size, which limited the possibility to include more potentially important modifiers of both GPx1 activity and TBARS levels, such as for example ER status. Finally, this study lacked data on patients’ survival, which obviously would give further insights into the clinical significance of the observed association between lipid peroxidation and GPX1 polymorphism.In the study presented here, plasma Se concentration was relatively low (29.1?9.9 g/L; Table 3) in all the study participants (being consistent with the fact of low dietary Se intake in Polish population [45]). However, it was not associated with the breast cancer risk. In general, the association between breast cancer and Se status remains controversial. Some case control studies have indicated the increased risk linked to the low dietary intake of the element, its low concentration in plasma/serum or low content in toe nails [46, 47] but no such association has been found in other studies, both with a retrospective [48] and a prospective approach [49?2]. Interestingly, the authors of one case control study, in which serum Se has been found to be lower in the breast cancer women (n = 200) as compared to the healthy controls (n = 200), have concluded that altered Se status was a consequence rather than a cause of cancer [46]. Potentially protective activity of Se com.