**Background** The renin-angiotensin system (RAS) is a complex hormonal cascade critical for regulating blood pressure, fluid balance, and various inflammatory responses. While the classical AngII/AT1R axis is primarily associated with…
**Background** Neutral endopeptidase (NEP) and aminopeptidase N (APN) are membrane-bound enzymes that play critical roles in the degradation of various endogenous opioid peptides. The dysregulation of these enzymes is often…
**Background** Olanzapine is a widely utilized atypical antipsychotic medication primarily prescribed for the treatment of schizophrenia and bipolar disorder. The pharmacological efficacy and safety profile of olanzapine are heavily influenced…
**Background** Protein arginine methyltransferases (PRMTs) play a critical role in the regulation of gene expression by catalyzing the transfer of methyl groups to arginine residues on various proteins, including histones.…
**Background** L-lysine is an essential amino acid for humans that plays a critical role in various physiological processes, including protein synthesis and calcium absorption. Beyond its nutritional value, L-lysine has…
**Background** Cancer metastasis, characterized by the migration and invasion of tumor cells into surrounding tissues and distant organs, is a primary driver of patient mortality. In various malignancies, such as…
**Background** Sigma receptors are a class of chaperone proteins involved in various cellular processes, including protein folding, calcium signaling, and the regulation of apoptosis. Among them, the sigma 2 ($\sigma_2$)…
**Background** The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that plays a critical role in regulating cell growth, proliferation, and survival. Mutations in EGFR are frequently associated with…