AMG-073 HCl (Cinacalcet hydrochloride) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. The current study evaluates the efficacy and safety of AMG 073 when added to conventional treatment of secondary hyperparathyroidism in end-stage renal disease (ESRD).

prudect name : AMG-073 HCl (Cinacalcet hydrochloride) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. The current study evaluates the efficacy and safety of AMG 073 when added to conventional treatment of secondary hyperparathyroidism in end-stage renal disease (ESRD).
AMG-073 HCl (Cinacalcet HCl)

Synonyms: AMG-073 HCl (Cinacalcet HCl)CAS NO: 364782-34-3Molecular Formula: C₂₂H₂₂F₃N.HClMolecular Weight: 393.87Purity: 98% minSolubility: In DMSOStorage: −20°C

123663-49-0 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18500329