Biological Activity Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 ¦ÌM respectively). Orally bioavailable.

June 21, 2017

prudect name : Biological Activity
Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC50 values are 0.87 and 0.91 ¦ÌM respectively). Orally bioavailable.

GNF 5837

Synonyms: CAS NO: 1033769-28-6Molecular Formula: C28H21F4N5O2Molecular Weight: 535.49Purity: 98% minSolubility: In DMSOStorage: -20°C


BMN 673 References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18518810