Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit ¦Á (eIF2¦Á). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 ¦ÌM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2¦Á phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2¦Á phosphorylation. Salubrinal inhibits eIF2¦Á dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3¦ÌM by inhibiting eIF2¦Á dephosphorylation. Salubrinal increased non-rapid eye movement (NREM) sleep.

June 21, 2017

prudect name : Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit ¦Á (eIF2¦Á). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 ¦ÌM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2¦Á phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2¦Á phosphorylation. Salubrinal inhibits eIF2¦Á dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3¦ÌM by inhibiting eIF2¦Á dephosphorylation. Salubrinal increased non-rapid eye movement (NREM) sleep.
Salubrinal

Synonyms: CAS NO: 405060-95-9Molecular Formula: C21H17Cl3N4OSMolecular Weight: 479.81Purity: 98% minSolubility: In DMSOStorage: -20°C


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