Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt. This agent is shown≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.

June 21, 2017

prudect name : Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt. This agent is shown≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.
Triciribine

Synonyms: CAS NO: 35943-35-2Molecular Formula: C₁₃H₁₆N₆O₄Molecular Weight: 320.3Purity: 98% minSolubility: In DMSOStorage: -20°C

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