Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. In vitro, two cell lines (OZ and HuCCT1), both of which harboured KRAS mutation, were refractory to vandetanib, one cell line (TGBC24TKB) was somewhat resistant, and another cell line (TKKK) was sensitive. The most sensitive cell line (TKKK) had EGFR amplification. Vandetanib (25 mg /kg/ day) significantly prolonged the time to metastasis in an intravenous model of TKKK metastasis.

June 21, 2017

prudect name : Vandetanib (Zactima) is a VEGFR and EGFR antagonist and a tyrosine kinase inhibitor with IC50 of 60, 90, 40 nM for HUVEC proliferation, PC-9 cells and tyrosine kinase activity, respectively. In vitro, two cell lines (OZ and HuCCT1), both of which harboured KRAS mutation, were refractory to vandetanib, one cell line (TGBC24TKB) was somewhat resistant, and another cell line (TKKK) was sensitive. The most sensitive cell line (TKKK) had EGFR amplification. Vandetanib (25 mg /kg/ day) significantly prolonged the time to metastasis in an intravenous model of TKKK metastasis.
Vandetanib (Zactima)

Synonyms: Vandetanib (Zactima)CAS NO: 443913-73-3Molecular Formula: C₂₂H₂₄BrFN₄O₂Molecular Weight: 475.35Purity: 99%Solubility: In DMSOStorage: -20°C

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