SB-590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration, which is distinct from the previously reported mechanism of action of the multi-kinase inhibitor, BAY43-9006.

June 21, 2017

prudect name : SB-590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration, which is distinct from the previously reported mechanism of action of the multi-kinase inhibitor, BAY43-9006.SB590885 Synonyms:…

📌

0💬 read more

StemRegenin 1(SR1) is an antagonist of the aryl hydrocarbon receptor.SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs).

prudect name : StemRegenin 1(SR1) is an antagonist of the aryl hydrocarbon receptor.SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood and cord blood…

📌

0💬 read more

prudect name : Side chain for meropenemSynonyms: CAS NO: 96034-64-9Molecular Formula: C15H19N3O5SMolecular Weight: 353.39Purity: 98%

prudect name : Side chain for meropenem Synonyms: CAS NO: 96034-64-9Molecular Formula: C15H19N3O5SMolecular Weight: 353.39Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com

📌

0💬 read more

Semaxanib, also known as SU5416, is a quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells.

prudect name : Semaxanib, also known as SU5416, is a quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth…

📌

0💬 read more

Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

prudect name : Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenolSKI II (SphK-I2) Synonyms: CAS NO: 312636-16-1Molecular Formula: C15H11ClN2OSMolecular Weight: 302.78Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

📌

0💬 read more

Dinaciclib is currently undergoing phase II clinical trial in the treatment of non-small-cell lung cancer.

prudect name : Dinaciclib is currently undergoing phase II clinical trial in the treatment of non-small-cell lung cancer.SCH727965 Synonyms: CAS NO: 779353-01-4Molecular Formula: C21H28N6O2Molecular Weight: 396.49Purity: 98% minSolubility: In DMSOStorage:…

📌

0💬 read more

Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-.alpha.-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-

prudect name : Avermectin A1a, 25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-.alpha.-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-Selamectin Synonyms: CAS NO: 165108-07-6Molecular Formula: C43H63NO11Molecular Weight: 769.96Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

📌

0💬 read more

SB-408124 (SB 408124)is a selective non-peptide orexin OX1 receptor antagonist .(Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). SB-408124 (SB 408124) blocks orexin-A induced grooming following oral administration in vivo.

prudect name : SB-408124 (SB 408124)is a selective non-peptide orexin OX1 receptor antagonist .(Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). SB-408124 (SB 408124)…

📌

0💬 read more

5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

prudect name : 5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineSGC 0946 SGC-0946 Synonyms: SGC0946CAS NO: 1561178-17-3Molecular Formula: C28H40BrN7O4Molecular Weight: 618.57Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years web site: www.medchemexpress.com

📌

0💬 read more

SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21. SU5614 is a PTK inhibitor of FLT3 and has antiproliferative and proapoptotic activity in AML-derived cell lines that endogenously express an activated FLT3 receptor.

prudect name : SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and…

📌

0💬 read more

Archive for June 2017