Archive for June 2017

In addition to Pim, SGI-1776 also potently targets FLT3 (IC50 = 44nM). Treatment of AML cells with SGI-1776 results in a concentration-dependent induction of apoptosis. Importantly, SGI-1776 is also cytotoxic in AML primary cells, irrespective of FLT3 mutation status and results in Mcl-1 protein decline.Treatment of CLL cells with SGI-1776 results in a concentration-dependent induction of apoptosis. SGI-1776 induces apoptosis in CLL and that the mechanism involves Mcl-1 reduction. Apoptosis induction coupled with the inhibition of RNA synthesis is observed in CLL cells treated with SGI-1776. SGI-1776 exhibites cytotoxic activity in vitro with a median relative IC50 of 3.1 mM. SGI-1776 induces tumor growth inhibition meeting criteria for intermediate EFS T/C activity in 1 of 39 evaluable models. In contrast, SGI-1776 induces complete responses of subcutaneous MV4;11.

 June 21, 2017

prudect name : In addition to Pim, SGI-1776 also potently targets FLT3 (IC50 = 44nM). Treatment of AML cells with SGI-1776 results in a concentration-dependent induction of apoptosis. Importantly, SGI-1776…

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prudect name : Sch 527123Synonyms: CAS NO: 473727-83-2Molecular Formula: C21H23N3O5Molecular Weight: 397.42Purity: 98% minSolubility: in

prudect name : Sch 527123 Synonyms: CAS NO: 473727-83-2Molecular Formula: C21H23N3O5Molecular Weight: 397.42Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38¦Á/¦Â with IC50 of 50 nM/100 nM, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo.

prudect name : SB202190 (FHPI) is a potent p38 MAPK inhibitor targeting p38¦Á/¦Â with IC50 of 50 nM/100 nM, sometimes used instead of SB 203580 to investigate potential roles for…

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prudect name : Sitaxsentan sodiumSynonyms: CAS NO: 210421-74-2Molecular Formula: C18H14ClN2NaO6S2Molecular Weight: 476.89Purity: 99%Solubility: In DMSOStorage:

prudect name : Sitaxsentan sodium Synonyms: CAS NO: 210421-74-2Molecular Formula: C18H14ClN2NaO6S2Molecular Weight: 476.89Purity: 99%Solubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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STF-118804 reduces the viability of B-ALL cell lines containing MLL chromosomal translations, with IC50 values in the low nanomolar range. In addition, leukemic samples from five pediatric ALL patients are also sensitive to STF-118804 in the low nanomolar range. STF-118804 induces leukemia MV411 cell apoptosis without antecedent cell cycle arrest.

prudect name : STF-118804 reduces the viability of B-ALL cell lines containing MLL chromosomal translations, with IC50 values in the low nanomolar range. In addition, leukemic samples from five pediatric…

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prudect name : SB-737050-ASynonyms: CAS NO: 630407-66-8Molecular Formula: Molecular Weight: Purity: 98% minSolubility: In DMSOStorage:

prudect name : SB-737050-A Synonyms: CAS NO: 630407-66-8Molecular Formula: Molecular Weight: Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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prudect name : sitafloxacin isomer II(RSR)Synonyms: CAS NO: 1271199-06-8Molecular Formula: C19H18CIF2N3O3Molecular Weight: 409.81Purity: ≥97%Solubility: Storage:

prudect name : sitafloxacin isomer II(RSR) Synonyms: CAS NO: 1271199-06-8Molecular Formula: C19H18CIF2N3O3Molecular Weight: 409.81Purity: ≥97%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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SCH772984 is a novel, selective and ATP competitive inhibitor of ERK1/2. SCH772984 inhibits phosphorylation of the ERK substrate p90 ribosomal S6 kinase (T359/S363 phospho-RSK) in a dose-dependent manner. SCH772984 also inhibits phosphorylation of residues in the activation loop of ERK itself. SCH772984 demonstrates EC50 values <500 nM in approximately 88% and 49% of BRAF-mutant or RAS-mutant tumor lines, respectively. Importantly, SCH772984 effectively inhibited MAPK signaling and cell proliferation in tumor cells resistant to concurrent treatment with BRAF and MEK inhibitors.

prudect name : SCH772984 is a novel, selective and ATP competitive inhibitor of ERK1/2. SCH772984 inhibits phosphorylation of the ERK substrate p90 ribosomal S6 kinase (T359/S363 phospho-RSK) in a dose-dependent…

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prudect name : StavudineSynonyms: CAS NO: 3056-17-5Molecular Formula: C10H12N2O4Molecular Weight: 224.22Purity: 99% minSolubility: Storage: −20°C

prudect name : Stavudine Synonyms: CAS NO: 3056-17-5Molecular Formula: C10H12N2O4Molecular Weight: 224.22Purity: 99% minSolubility: Storage: −20°C web site: www.medchemexpress.com

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SNS-314 Mesylate is an ATP-competitive, potent and selective inhibitor of Aurora kinases A (IC50=9.0nM), B (IC50=31nM), and C (IC50=3.4nM). SNS-314 demonstrated remarkable specificity and was found to inhibit only 24 of 219 kinases by 65% greater than that of screening at 1 µM. Histone H3 phosphorylation was potently inhibited by SNS-314 in all 6 cell lines tested with IC50 values ranging from 9 nM in HCT116 cellsto 60 nM in Calu-6 cells .SNS-314 Mesylate also displayed significant anti-tumor activity in mouse xenograft models of human breast (MDA-MB-231), prostate (PC-3), lung (H1299 and Calu-6), ovarian (A2780) carcinomas and melanoma (A375).

prudect name : SNS-314 Mesylate is an ATP-competitive, potent and selective inhibitor of Aurora kinases A (IC50=9.0nM), B (IC50=31nM), and C (IC50=3.4nM). SNS-314 demonstrated remarkable specificity and was found to…

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