Archive for June 2017

Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Upon administration, radotinib specifically inhibits the Bcr-Abl fusion protein, an abnormal enzyme expressed in Philadelphia chromosome-positive chronic myeloid leukemia (CML) cells. In addition, this agent also inhibits PDGFR thereby blocking PDGFR-mediated signal transduction pathways. The inhibitory effect of radotinib on these specific tyrosine kinases may decrease cellular proliferation and inhibit angiogenesis. This agent has shown potent efficacy in CML cells that are resistant to the first-generation standard tyrosine kinase inhibitors, such as imatinib, nilotinib and dasatinib. PDGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature.

 June 21, 2017

prudect name : Radotinib, also known as IY-5511, is an orally available, hydrochloride salt form of radotinib, a second-generation tyrosine kinase inhibitor of Bcr-Abl fusion protein and the platelet-derived growth…

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prudect name : Raltegravir potassiumSynonyms: CAS NO: 871038-72-1Molecular Formula: C20H20FKN6O5Molecular Weight: 482.51Purity: 99%Solubility: Storage: −20°C

prudect name : Raltegravir potassium Synonyms: CAS NO: 871038-72-1Molecular Formula: C20H20FKN6O5Molecular Weight: 482.51Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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prudect name : RamiprilSynonyms: CAS NO: 87333-19-5Molecular Formula: C23H32N2O5Molecular Weight: 416.52Purity: ≥99%Solubility: Storage: −20°C

prudect name : Ramipril Synonyms: CAS NO: 87333-19-5Molecular Formula: C23H32N2O5Molecular Weight: 416.52Purity: ≥99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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Remodelin is a potent acetyl-transferase NAT10 inhibitor.Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and fitness of HGPS cells. Remodelin may thus provide opportunities for alleviating dystrophic and premature-ageing diseases

prudect name : Remodelin is a potent acetyl-transferase NAT10 inhibitor.Remodelin, via inhibition of NAT10, mediates nuclear shape rescue of LMNA depleted cells by microtubule reorganization, and improves nuclear shape and…

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prudect name : R-428Synonyms: R428CAS NO: 1037624-75-1Molecular Formula: C30H34N8Molecular Weight: 506.64Purity: 98% minSolubility: In DMSOStorage:

prudect name : R-428 Synonyms: R428CAS NO: 1037624-75-1Molecular Formula: C30H34N8Molecular Weight: 506.64Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

prudect name : RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).RO8994…

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rapamycin inhibited the proliferation of primary bone marrow cells induced by IL-3, GM-CSF, KL, or a complex mixture of factors present in cell-conditioned media. Rapamycin also inhibited the multiplication of colony-forming cells in suspension cultures containing IL-3 plus interleukin-1 (IL-1) or interleukin-11 (IL-11) plus KL.

prudect name : rapamycin inhibited the proliferation of primary bone marrow cells induced by IL-3, GM-CSF, KL, or a complex mixture of factors present in cell-conditioned media. Rapamycin also inhibited…

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Chemical Name: 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine; MT500

prudect name : Chemical Name: 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine; MT500RS127445 Synonyms: CAS NO: 199864-87-4Molecular Formula: C17H16FN3Molecular Weight: 281.33Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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1-(morpholinoethyl)-4-nitroimidazole; 4-[2-(4-nitro-imidazol-1-yl)-ethyl]-morpholine; N-(Î2-Morpholinoethyl)-4-nitroimidazol; 1-(2-Morpholinoethyl)-4-nitroimidazol

prudect name : 1-(morpholinoethyl)-4-nitroimidazole; 4-[2-(4-nitro-imidazol-1-yl)-ethyl]-morpholine; N-(Î2-Morpholinoethyl)-4-nitroimidazol; 1-(2-Morpholinoethyl)-4-nitroimidazolRGW 611 Synonyms: CAS NO: 6497-78-5Molecular Formula: C9H14N4O3Molecular Weight: 226.24Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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prudect name : RoMidepsin Depsipeptide(FK-228,NSC-63017)Synonyms: RoMidepsin Depsipeptide(FK-228,NSC-63017)CAS NO: 128517-07-7Molecular Formula: C24H36N4O6S2Molecular Weight: 540.70Purity: 98% minSolubility:

prudect name : RoMidepsin Depsipeptide(FK-228,NSC-63017) Synonyms: RoMidepsin Depsipeptide(FK-228,NSC-63017)CAS NO: 128517-07-7Molecular Formula: C24H36N4O6S2Molecular Weight: 540.70Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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