Ge), specially made to separate urine and faeces andS. no. 1 2 3 four five

November 27, 2023

Ge), specially made to separate urine and faeces andS. no. 1 2 3 four five groups Handle (10 ml/Kg b. wt) Regular (Frusemide 10 mg/kg b.wt) alcoholic extract of roots of C.pareira Low (one hundred mg/kg b.wt) Alcoholic extract of roots of C.pareira Medium (200 mg/kg b.wt) Alcoholic extract of roots of C.pareira High (400 mg/kg b.wt)DISCUSSIONMedicinal plants and botanicals supply a organic safeguard against diseases and are a substantial treatment for specific illnesses. Diuretics have proved to become particularly precious inside the therapy of mild to moderate hypertension and also in enhancing the impact of other antihypertensive agents. Diuretics relieve pulmonary congestion and peripheral oedema. These agents are useful in decreasing volume over load and relieve orthopnea and paroxysmal nocturnal dyspnoea [19] in CCF and acute left ventricular failure. They reduce CB1 Activator review plasma volume and subsequently venous return for the heart. This decreases the cardiac operate load, oxygen demand and plasma volume as well as decreases blood pressure. Thusna+ mmol/l 113.03 + 2.16 191.05+2.09 129.40+2. total urine Vol (ml/kg b.wt/5 h) 13.45?.02 22.23?.01 15.20?. K+ mmol/l 51.09 + 1.51 87.81+1.60 64.13+1. Cl- mmol/l 82.95 + 1.42 129.06+1.67 94.42 + 1.73 109.44+1.20 121.39+2.0017.41?.02 20.46?.164.99+2.00 184.53+2.77.93+2.67 85.11+1.[Table/Fig-1]: Effect of alcoholic extract of roots of Cissampelos pareira on urine volume and electrolyte concentration in hydrated rat model in albino rats Values expressed as imply ?S.E.M.,n=6, Significance at p0.05, p0.01, p0.001, Compared with manage group (A single Way ANOVA followed by Dunnetts `t’ test).Journal of Clinical and Diagnostic Research. 2014 May possibly, Vol-8(five): HC01-HCjcdr.netSuresh Babu Sayana et al., Evaluation of Diuretic Activity of Alcoholic Extract of Roots of Cissampelos Pareira in Albino Ratssaponins, organic acids [1,17], steroids, carbohydrates, GSK-3 Inhibitor web tannins, phenolic compounds, terpenoids [22], alkaloids [23], glycosides [24], sterols [25], sesquiterpenes aminoacids, carotinoids [26] in distinctive plant extracts. Alcoholic extract of roots of Cissampelos pareira was identified with most of these plant phytochemical substances pointed out above. Therefore it may be reported that the observed diuretic activity is because of these above phytoconstituents.CONCLUSIONResults showed that single dose administration of alcoholic extract of roots of Cissampelos pareira as one hundred,200 and 400 mg/Kg and regular Furosemide (10 mg/kg) have improved the urinary output together with a rise in concentration of Sodium, Potassium and Chloride ions in urine. Alcoholic extract of roots of Cissampelos pareira mg/Kg created a higher diuretic activity which is comparable to that of normal Furosemide (ten mg/kg). In classic medicine the plant is made use of for its diuretic activity. Ours scientific study come up with identification of lots of phytoconstituents reported earlier for this diuretic effect in our alcoholic extract of roots of Cissampelos pareira. As a result our study supports and justifies the rationale behind the folklore use of roots of C.pareira for its diuretic activity.[Table/Fig-2]: Effect of alcoholic extract of roots of c. pareira on urinary sodium, pot assium, chloride (mmol/l) ions concentration in hydrated rat model in albino ratsACkNOwLEDGEMENTSThe authors are very much grateful to Dr. S.M.Shanth Kumar Ex Principal, V.L. College of Pharmacy and Dr. V.Hemanth Kumar Principal V.L. College of Pharmacy, Raichur, Karnataka for supplying the laboratory facil.