Rabbit anti-FGB Polyclonal Antibody

April 19, 2025

Product Name :
Rabbit anti-FGB Polyclonal Antibody

Synonym :
HEL-S-78p

Host :
Rabbit

Species Reactivity:
Human, Mouse, Rat

Specificity :

Predicted Reactivity:

Applications :
WB 1:500 – 1:2000

Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 202-491 of human FGB (NP_005132.2).

Concentration :

Purification :
Affinity purification

Clonality:
Polyclonal Antibody

Storage Temp.:
Store at -20 ℃Avoid freeze / that cycles

Research areas :

Background :
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt :
P02675

Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Synonym HEL-S-78p |Host Rabbit |Species Reactivity Human, Mouse, Rat |Applications WB 1:500 – 1:2000 |Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 202-491 of human FGB (NP_005132.2). |Positive control Mouse heart,Mouse liver |Properties |Purification Affinity purification |Clonality Polyclonal Antibody |Isotype IgG |Storage Temp. Store at -20 ℃Avoid freeze / that cycles |Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |Target |Background The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |Cellular localization Secreted |UniProt P02675 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.

Rabbit anti-FGB Polyclonal Antibody

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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