VD/VDR- vd-vdr

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Posts by VD/VDR- vd-vdr

GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line .For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 µmol/L for GDC-0879).

 June 21, 2017

prudect name : GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified…

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E-7050 is hepatocyte growth factor receptors (HGFR).

prudect name : E-7050 is hepatocyte growth factor receptors (HGFR).Golvatinib (E7050) Synonyms: Golvatinib (E7050)CAS NO: 928037-13-2Molecular Formula: C33H37F2N7O4Molecular Weight: 633.69Purity: 98% minSolubility: In DMSOStorage: −20°C VX809 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18515349

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FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 ¦ÌM.In HeLa Notch¦¤E-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid ¦Â. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER.

prudect name : FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 ¦ÌM.In HeLa Notch¦¤E-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern…

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5S rRNA modificator is a suitable electrophile for 2¡¯-hydroxyl acylation on structured RNA molecules, yielding accurate structural information comparable to that obtained with existing probes; 5S rRNA RNA modification.

prudect name : 5S rRNA modificator is a suitable electrophile for 2¡¯-hydroxyl acylation on structured RNA molecules, yielding accurate structural information comparable to that obtained with existing probes; 5S rRNA…

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G-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase in clinical development for the treatment of anemia. FG-4592 stabilizes the activitiues of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including EPO and enzymes involved in iron metabolism.

prudect name : G-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase in clinical development for the treatment of anemia. FG-4592 stabilizes the activitiues of HIF, a…

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Fleroxacin mechanism of bacterial DNA by inhibiting the enzyme into the sky bactericidal effect of rotation.

prudect name : Fleroxacin mechanism of bacterial DNA by inhibiting the enzyme into the sky bactericidal effect of rotation.Fleroxacin Synonyms: CAS NO: 79660-72-3Molecular Formula: C17H18F3N3O3Molecular Weight: 369.34Purity: ≥99%Solubility: Storage: −20°C…

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prudect name : Fasudil hydrochlorideSynonyms: CAS NO: 105628-07-7Molecular Formula: C14H17N3O2S.HClMolecular Weight: 327.83Purity: 99%Solubility: Storage: −20°C

prudect name : Fasudil hydrochloride Synonyms: CAS NO: 105628-07-7Molecular Formula: C14H17N3O2S.HClMolecular Weight: 327.83Purity: 99%Solubility: Storage: −20°C 2 years Nazartinib References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18515280

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Fondaparinux sodium is a new liver Kuei anticoagulant drug, is a synthetic, selective inhibitor of activated factor X.

prudect name : Fondaparinux sodium is a new liver Kuei anticoagulant drug, is a synthetic, selective inhibitor of activated factor X.Fondaparinux sodium Synonyms: CAS NO: 114870-03-0Molecular Formula: C31H43N3Na10O49S8Molecular Weight: 1728.08Purity:…

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cis-(Z)-Flupenthixol dihydrochloride; (Z)-4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochloride

prudect name : cis-(Z)-Flupenthixol dihydrochloride; (Z)-4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol dihydrochlorideFlupenthixol dihydrochloride Synonyms: CAS NO: 51529-01-2Molecular Formula: C23H25F3N2OS.2(HCl)Molecular Weight: 507.44Purity: 98% minSolubility: In DMSOStorage: −20°C 2 years ASP-2215 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18515255

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Fulvestrant (Faslodex) is a synthetic estrogen receptor antagonist or selective estrogen receptor down-regulator (SERD). Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. Fulvestrant is used for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy.

prudect name : Fulvestrant (Faslodex) is a synthetic estrogen receptor antagonist or selective estrogen receptor down-regulator (SERD). Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce…

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