5,11-Dimethyl-6H-pyrido[4,3-b]carbazole

June 21, 2017

prudect name : 5,11-Dimethyl-6H-pyrido[4,3-b]carbazoleEllipticine Synonyms: CAS NO: 519-23-3Molecular Formula: C17H14N2Molecular Weight: 246.31Purity: 98% minSolubility: In DMSOStorage: -20 oC ONT-380 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18514005

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EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby inhibiting the methylation of nucleosomal histone H3 on lysine 79 (H3K79) that is bound to the mixed lineage leukemia (MLL) fusion protein which targets genes and blocks the expression of leukemogenic genes. This eventually leads to an induction of apoptosis in the leukemic cells bearing the MLL gene translocations. DOT1L, a non-SET domain-containing histone methyltransferase, specifically methylates H3K79 and plays a key role in normal cell differentiation and in the development of leukemia with MLL gene rearrangement on chromosome 11 and promotes the expression of leukemia-causing genes.

prudect name : EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby…

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prudect name : Estradiol benzoateSynonyms: CAS NO: 50-50-0Molecular Formula: C25H28O3Molecular Weight: 376.49Purity: 98% minSolubility: Storage:

prudect name : Estradiol benzoate Synonyms: CAS NO: 50-50-0Molecular Formula: C25H28O3Molecular Weight: 376.49Purity: 98% minSolubility: Storage: −20°C SCH 420814 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18513969

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Everolimus(RAD001), is a 40-O-(2-hydroxyethyl) derivative of rapamycin with immunosuppressant and anti-angiogenic properties, which exhibits improved aqueous solubility relative to the parent compound for oral administration. In cells, Everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of mTOR. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production

prudect name : Everolimus(RAD001), is a 40-O-(2-hydroxyethyl) derivative of rapamycin with immunosuppressant and anti-angiogenic properties, which exhibits improved aqueous solubility relative to the parent compound for oral administration. In cells,…

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Eltrombopag is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. Eltrombopag was approved by FDA in November 20, 2008.

prudect name : Eltrombopag is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110),…

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(3aS,4R,9bR)-1,2,3,3a,4,9b-Hexahydro-4-(4-hydroxyphenyl)cyclopenta[c][1]benzopyran-8-ol

prudect name : (3aS,4R,9bR)-1,2,3,3a,4,9b-Hexahydro-4-(4-hydroxyphenyl)cyclopenta[c][1]benzopyran-8-olErteberel Synonyms: CAS NO: 533884-09-2Molecular Formula: C18H18O3Molecular Weight: 282.33Purity: 98% minSolubility: In DMSOStorage: -20°C R207910 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18513887

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Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. It inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM.

prudect name : Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. It inhibits proteasome activity in…

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Entospletinib, also known as GS-9973, is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications.

prudect name : Entospletinib, also known as GS-9973, is a highly selective and orally efficacious Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indications.Entospletinib Synonyms: GS-9973;…

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Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.

prudect name : Eptifibatide is an antiplatelet drug of the glycoprotein IIb/IIIa inhibitor class.Eptifibatide Synonyms: CAS NO: 188627-80-7 148031-34-9Molecular Formula: C35H49N11O9S2Molecular Weight: 831.96Purity: 98% minSolubility: in DMSOStorage: -20oC AZD 7762…

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prudect name : ECBC hcl; 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1)Synonyms: CAS NO: 1029890-89-8Molecular Formula: C34H51N7O15.HClMolecular Weight:

prudect name : ECBC hcl; 1-[(4R,5R)-4,5-Dihydroxy-L-ornithine]echinocandin B hydrochloride (1:1) Synonyms: CAS NO: 1029890-89-8Molecular Formula: C34H51N7O15.HClMolecular Weight: 834.27Purity: 90% minSolubility: Storage: -20oC BAY-41-2272 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18513795

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