VD/VDR- vd-vdr

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Posts by VD/VDR- vd-vdr

DY131, a selective ERR¦Ã agonist, could potentiate the ERR¦Ã-induced growth inhibition in LNCaP- ERR¦Ã and DU145- ERR¦Ã cells in a dose-dependent manner compared with respective parental cells. DY131 inhibited the growth of the ER¦Á-positive endometrial cancer cells but promoted that of the ER¦Á-negative cancer cells. DY131 had no effect on the structurally related receptors ERR¦Á or the estrogen receptors alpha and beta (ERalpha/beta). DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists.

 June 21, 2017

prudect name : DY131, a selective ERR¦Ã agonist, could potentiate the ERR¦Ã-induced growth inhibition in LNCaP- ERR¦Ã and DU145- ERR¦Ã cells in a dose-dependent manner compared with respective parental cells….

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Dimethyloxallyl Glycine(DMOG) is a cell permeable, competitive inhibitor of HIF-PH(HIF-1¦Á prolyl hydroxylase).

prudect name : Dimethyloxallyl Glycine(DMOG) is a cell permeable, competitive inhibitor of HIF-PH(HIF-1¦Á prolyl hydroxylase).Dimethyloxaloylglycine (DMOG) Synonyms: CAS NO: 89464-63-1Molecular Formula: C6H9NO5Molecular Weight: 175.14Purity: 98% minSolubility: Storage: -20oC FG4592 References…

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DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM).

prudect name : DDR1-IN-1 is a potent and selective DDR1 receptor tyrosine kinase inhibitor with IC50/EC50 of 105 nM/87 nM; 4-fold less potent for DDR2 (IC50= 413 nM).DDR1-IN-1 Synonyms: CAS…

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Dapagliflozin(BMS-512148) is a potent sodium-glucose transport proteins inhibitor with IC50 of 1.1 nM and 1.4uM for SGLT2 and SGLT1, respectively. Dapagliflozin (BMS-512148) inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. Symptoms of hypoglycaemia occurred in similar proportions of patients in the dapagliflozin (2~4%) and placebo groups (3%). Signs, symptoms, and other reports suggestive of genital infections were more frequent in the dapagliflozin groups (2•5 mg, [8%]; 5 mg, [13%]; 10 mg, [9%]) than in the placebo group ( [5%]).

prudect name : Dapagliflozin(BMS-512148) is a potent sodium-glucose transport proteins inhibitor with IC50 of 1.1 nM and 1.4uM for SGLT2 and SGLT1, respectively. Dapagliflozin (BMS-512148) inhibits subtype 2 of the…

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prudect name : D-(+)-Methyl-alpha-(2-thienylethamino)(2-chlorophenyl)acetate hydrochlorideSynonyms: CAS NO: 141109-19-5Molecular Formula: C15H16ClNO2S.HClMolecular Weight: 346.27Purity: ≥98%Solubility: Storage: −20°C

prudect name : D-(+)-Methyl-alpha-(2-thienylethamino)(2-chlorophenyl)acetate hydrochloride Synonyms: CAS NO: 141109-19-5Molecular Formula: C15H16ClNO2S.HClMolecular Weight: 346.27Purity: ≥98%Solubility: Storage: −20°C 2 years SB 1518 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511703

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prudect name : DidanosineSynonyms: CAS NO: 69655-05-6Molecular Formula: C10H12N4O3Molecular Weight: 236.23Purity: 99% minSolubility: Storage: −20°C

prudect name : Didanosine Synonyms: CAS NO: 69655-05-6Molecular Formula: C10H12N4O3Molecular Weight: 236.23Purity: 99% minSolubility: Storage: −20°C PD-0332991 isethionate References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511691

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N2¡¯-Deacetyl-N2¡¯-(3-mercapto-1-oxopropyl)maytansine

prudect name : N2¡¯-Deacetyl-N2¡¯-(3-mercapto-1-oxopropyl)maytansineDM 1; Maytansinoid DM 1 Synonyms: CAS NO: 139504-50-0Molecular Formula: C35H48ClN3O10SMolecular Weight: 738.29Purity: 98% minSolubility: DMSOStorage: -20¡æ AZD1775 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511687

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Detomidine hydrochloride is a nonnarcotic, synthetic alpha-2 adrenoreceptor agonist. equine sedative/analgesic that contains the active ingredient detomidine hydrochloride. Detomidine is a sedative with analgesic properties. Alpha2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of alpha-2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.

prudect name : Detomidine hydrochloride is a nonnarcotic, synthetic alpha-2 adrenoreceptor agonist. equine sedative/analgesic that contains the active ingredient detomidine hydrochloride. Detomidine is a sedative with analgesic properties. Alpha2-adrenergic agonists…

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Deforolimus (Ridaforolimus) is a small-molecule inhibitor of mTOR. It is an immunosuppressant for the treatment of certain cancers. Blocking mTOR creates a starvation-like effect in cancer cells by interfering with cell growth, division, metabolism, and angiogenesis.

prudect name : Deforolimus (Ridaforolimus) is a small-molecule inhibitor of mTOR. It is an immunosuppressant for the treatment of certain cancers. Blocking mTOR creates a starvation-like effect in cancer cells…

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prudect name : DesogestrelSynonyms: CAS NO: 54024-22-5Molecular Formula: C22H30OMolecular Weight: 310.48Purity: 98% minSolubility: Storage: −20°C

prudect name : Desogestrel Synonyms: CAS NO: 54024-22-5Molecular Formula: C22H30OMolecular Weight: 310.48Purity: 98% minSolubility: Storage: −20°C VX765 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511601

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