VD/VDR- vd-vdr

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Posts by VD/VDR- vd-vdr

BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 ¦ÌM. Its treatment had little effect on tumor cell growth but inhibited cell scattering activated by exogenous HGF, with almost complete inhibition at 0.5 ¦Ìmol/L in PC-3 and DU145 cells. This agent also suppressed HGF-stimulated cell migration and invasion in a dose-dependent fashion (IC50 < 0.1 ¦Ìmol/L) in both cell lines. Mechanistically, nanomolar doses of BMS 777607 potently blocked HGF-stimulated c-Met autophosphorylation and downstream activation of Akt and extracellular signal-regulated kinase. In addition, both wortmannin and U0126, but not dasatinib, attenuated cell scattering and migration induced by HGF, suggesting the involvement of the phosphoinositide 3-kinase and mitogen-activated protein kinase pathways, but not of Src or focal adhesion kinase, in HGF-mediated motogenic effects.

 June 21, 2017

prudect name : BMS 777607 is a Small-Molecule Met Kinase Inhibitor with an IC50 of < 0.1 ¦ÌM. Its treatment had little effect on tumor cell growth but inhibited cell...

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Brexpiprazole is a novel D2 dopamine partial agonist.

prudect name : Brexpiprazole is a novel D2 dopamine partial agonist.Brexpiprazole Synonyms: CAS NO: 913611-97-9Molecular Formula: C25H27N3O2SMolecular Weight: 433.57Purity: 98% minSolubility: In DMSOStorage: -20 oC ABT-627 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18505087

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BMS-626529 is a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T-cells.

prudect name : BMS-626529 is a novel small-molecule attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T-cells.BMS 626529 Synonyms: CAS NO: 701213-36-7Molecular Formula: C24H23N7O4Molecular Weight: 473.48Purity:…

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is the treatment of eye drops and ocular hypertension open-angle glaucoma relief elevated intraocular pressure in patients with a better drug

prudect name : is the treatment of eye drops and ocular hypertension open-angle glaucoma relief elevated intraocular pressure in patients with a better drugBrinzolamide Synonyms: CAS NO: 138890-62-7Molecular Formula: C12H21N3O5S3Molecular…

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prudect name : BusulfanSynonyms: CAS NO: 55-98-1Molecular Formula: C6H14O6S2Molecular Weight: 246.29Purity: 99%Solubility: Storage: −20°C

prudect name : Busulfan Synonyms: CAS NO: 55-98-1Molecular Formula: C6H14O6S2Molecular Weight: 246.29Purity: 99%Solubility: Storage: −20°C 2 years GFT505 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504903

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BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectively

prudect name : BLU9931 is a potent, selective, and irreversible FGFR4 inhibitor with IC50 of 3 nM, about 297-, 184-, and 50-fold selectivity over FGFR1/2/3, respectivelyBLU9931 Synonyms: CAS NO: 1538604-68-0Molecular…

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Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It has also been used and prescribed off-label to lengthen eyelashes.

prudect name : Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure…

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Bosentan reduces pulmonary vascular resistance, pulmonary vascular and right reversing ventricular hypertrophy

prudect name : Bosentan reduces pulmonary vascular resistance, pulmonary vascular and right reversing ventricular hypertrophyBosentan hydrate Synonyms: CAS NO: 157212-55-0Molecular Formula: C27H29N5O6S.H2OMolecular Weight: 569.63Purity: ≥99%Solubility: Storage: −20°C 2 years AZD0530…

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prudect name : Butoconazole nitrateSynonyms: CAS NO: 64872-77-1Molecular Formula: C19H17Cl3N2S.HNO3Molecular Weight: 474.79Purity: 99%Solubility: Storage: −20°C

prudect name : Butoconazole nitrate Synonyms: CAS NO: 64872-77-1Molecular Formula: C19H17Cl3N2S.HNO3Molecular Weight: 474.79Purity: 99%Solubility: Storage: −20°C 2 years Torin1 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504684

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B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM).

prudect name : B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM).B-Raf IN 1 Synonyms: CAS NO:…

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