VD/VDR- vd-vdr

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Posts by VD/VDR- vd-vdr

prudect name : BMS-946815Synonyms: BMS946815CAS NO: 244154-66-3Molecular Formula: C24H30CIN3O4Molecular Weight: 459.19Purity: 98% minSolubility: In DMSOStorage:

 June 21, 2017

prudect name : BMS-946815 Synonyms: BMS946815CAS NO: 244154-66-3Molecular Formula: C24H30CIN3O4Molecular Weight: 459.19Purity: 98% minSolubility: In DMSOStorage: −20°C AZD-1775 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504307

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prudect name : Bicyclo[2.2.2]Octane-1,4-Dicarboxylic AcidSynonyms: CAS NO: 711-02-4Molecular Formula: C10H14O4Molecular Weight: 198.2158Purity: 98% minSolubility: Storage:

prudect name : Bicyclo[2.2.2]Octane-1,4-Dicarboxylic Acid Synonyms: CAS NO: 711-02-4Molecular Formula: C10H14O4Molecular Weight: 198.2158Purity: 98% minSolubility: Storage: −20°C Pevonedistat References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504295

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prudect name : BlonanserinSynonyms: CAS NO: 132810-10-7Molecular Formula: C23H30FN3Molecular Weight: 367.50Purity: 98% minSolubility: Storage: -20°C

prudect name : Blonanserin Synonyms: CAS NO: 132810-10-7Molecular Formula: C23H30FN3Molecular Weight: 367.50Purity: 98% minSolubility: Storage: -20°C Seviteronel References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504291

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BIBR 953(Dabigatran) is a reversible, competitive, direct thrombin inhibitor. It has been shown to be an effective antithrombotic agent in animal models and to be efficacious and safe in the prevention of deep vein thrombosis in patients undergoing elective total hip or knee replacement.

prudect name : BIBR 953(Dabigatran) is a reversible, competitive, direct thrombin inhibitor. It has been shown to be an effective antithrombotic agent in animal models and to be efficacious and…

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BMS-345541 is a cell-permeable quinoxaline compound that shows anti-inflammatory properties. BMS-345541 is a potent, selective, and allosteric site-binding inhibitor of IKK ¦Â (IKK-2). Displays ~10-fold greater selectivity over IKK ¦Á (IKK-1) and no activity towards IKK¦Å and a panel of more than 15 unrelated protein kinases even at concentrations as high as 100 ¦ÌM. Inhibits cellular I¦ÊB¦Á phosphorylation.

prudect name : BMS-345541 is a cell-permeable quinoxaline compound that shows anti-inflammatory properties. BMS-345541 is a potent, selective, and allosteric site-binding inhibitor of IKK ¦Â (IKK-2). Displays ~10-fold greater selectivity…

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BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G-protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched-1 in the SHH pathway; in the absence of ligand Patched-1 inhibits SMO and ligand binding to Patched-1 results in increased levels of SMO. The SHH signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.

prudect name : BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which…

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prudect name : BazedoxifeneSynonyms: CAS NO: 198481-32-2Molecular Formula: C30H34N2O3Molecular Weight: 470.6026Purity: 98% minSolubility: In DMSOStorage:

prudect name : Bazedoxifene Synonyms: CAS NO: 198481-32-2Molecular Formula: C30H34N2O3Molecular Weight: 470.6026Purity: 98% minSolubility: In DMSOStorage: -20°C Apabetalone References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18504058/

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Insulin-like Growth Factor-1 Receptor Inhibitor; 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone

prudect name : Insulin-like Growth Factor-1 Receptor Inhibitor; 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinoneBMS-536924 Synonyms: CAS NO: 468740-43-4Molecular Formula: C25H26ClN5O3Molecular Weight: 479.96Purity: 98% minSolubility: In DMSOStorage: -20°C IPI-549 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1850405

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BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.

prudect name : BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated…

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prudect name : BiapenemSynonyms: CAS NO: 120410-24-4Molecular Formula: C15H18N4O4SMolecular Weight: 350.39Purity: 98% minSolubility: Storage: −20°C

prudect name : Biapenem Synonyms: CAS NO: 120410-24-4Molecular Formula: C15H18N4O4SMolecular Weight: 350.39Purity: 98% minSolubility: Storage: −20°C GDC-0199 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503899

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