prudect name : Bafilomycin A1Synonyms: CAS NO: 88899-55-2Molecular Formula: C35H58O9Molecular Weight: 622.83Purity: 98% minSolubility: Storage:

June 21, 2017

prudect name : Bafilomycin A1 Synonyms: CAS NO: 88899-55-2Molecular Formula: C35H58O9Molecular Weight: 622.83Purity: 98% minSolubility: Storage: −20°C KPT-9274 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503878

📌

0💬 read more

BMS-806, a 7-azaindole derivative, binds gp120 and interferes with the interaction of HIV surface protein gp120 with the host cell receptor CD4. BMS-806 inhibits a panel of macrophage- and T cell-tropic HIV-1 strains, which are laboratory strains that use either CCR5 (M-tropic) or CXR4 (T-tropic) co-receptors to enter cells and are classified as B subtypes. The aqueous solubility from the crystalline form of BMS-806 (BMS 378806) is 170 ¦Ìg/mL. The solubility of BMS-806 is 1.3 mg/mL at pH=2.1 and 3.3 mg/mL at pH=11, a solubility profile that reveals the amphoteric nature of BMS-806 and estimates the pKa of the protonated form as 2.9 while that of the free base is approximately 9.6. BMS-806 competes with soluble CD4 binding to a monomeric form of gp120 in an ELISA assay with IC50 = ~ 100 nM. BMS-806 is specific towards HIV-1, with no significant inhibitory activity against HIV-2, SIV, MuLV, RSV, HCMV, BVDV, VSV, and influenza virus observed at concentrations ranging from 10 to 30 ¦ÌM and no overt cytotoxicity toward host cells, CC50 values > 225 ¦ÌM. BMS-806 binds directly to gp120 at a stoichiometry of approximately 1:1, with a binding affinity similar to that of soluble CD4. The potential BMS-806 target site is localized to a specific region within the CD4 binding pocket of gp120 by using HIV-1 gp120 variants carrying either compound-selected resistant substitutions or gp120-CD4 contact site mutations.

prudect name : BMS-806, a 7-azaindole derivative, binds gp120 and interferes with the interaction of HIV surface protein gp120 with the host cell receptor CD4. BMS-806 inhibits a panel of…

📌

0💬 read more

prudect name : Bremelanotide PT 141Synonyms: CAS NO: 189691-06-3Molecular Formula: C50H68N14O10Molecular Weight: 1025.16Purity: 98% minSolubility:

prudect name : Bremelanotide PT 141 Synonyms: CAS NO: 189691-06-3Molecular Formula: C50H68N14O10Molecular Weight: 1025.16Purity: 98% minSolubility: Storage: -20°C ABT-263 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503854

📌

0💬 read more

BMS-790052 is a first-in-class, highly-selective oral HCV NS5A inhibitor. NS5A is an essential component for hepatitis C virus (HCV) replication complex. BMS-790052 has broad genotype coverage and exhibits picomolar in vitro potency against genotypes 1a (EC50 50pm) and 1b (EC50 9pm). BMS-790052 produces a robust decline in HCV RNA (-3.6 logs after 48 hours from a single 100 mg) dosefollowing a single dose in patients chronically infected with HCV genotype 1.

prudect name : BMS-790052 is a first-in-class, highly-selective oral HCV NS5A inhibitor. NS5A is an essential component for hepatitis C virus (HCV) replication complex. BMS-790052 has broad genotype coverage and…

📌

0💬 read more

BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. IGF-1R antagonist BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways; inhibition of IGF-1R-mediated signaling pathways may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a receptor tyrosine kinase expressed on most tumor cells and is involved in mitogenesis, angiogenesis, and tumor cell survival.

prudect name : BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. IGF-1R antagonist BMS-7548077 binds to IGF-1R, preventing IGF-1…

📌

0💬 read more

prudect name : BexaroteneSynonyms: CAS NO: 153559-49-0Molecular Formula: C24H28O2Molecular Weight: 348.48Purity: 98% minSolubility: In DMSOStorage:

prudect name : Bexarotene Synonyms: CAS NO: 153559-49-0Molecular Formula: C24H28O2Molecular Weight: 348.48Purity: 98% minSolubility: In DMSOStorage: -20°C ABEMACICLIB References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503802

📌

0💬 read more

prudect name : Bencynoate hydrochlorideSynonyms: CAS NO: 162220-36-2Molecular Formula: C22H32ClNO3Molecular Weight: 393.95Purity: 98% minSolubility: Storage:

prudect name : Bencynoate hydrochloride Synonyms: CAS NO: 162220-36-2Molecular Formula: C22H32ClNO3Molecular Weight: 393.95Purity: 98% minSolubility: Storage: −20°C Niraparib References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503774

📌

0💬 read more

BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PKD1 than PKA and PKC, respectively. In comparison to GSK3¦Â, selectivity for PDK1 is 600-fold.

prudect name : BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PKD1 than PKA and PKC, respectively. In…

📌

0💬 read more

prudect name : BI-D1870Synonyms: CAS NO: 501437-28-1Molecular Formula: C19H23F2N5O2Molecular Weight: 391.42Purity: 98% minSolubility: in DMSOStorage:

prudect name : BI-D1870 Synonyms: CAS NO: 501437-28-1Molecular Formula: C19H23F2N5O2Molecular Weight: 391.42Purity: 98% minSolubility: in DMSOStorage: -20oC DX8951f References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503755

📌

0💬 read more

prudect name : BAN ORL 24Synonyms: CAS NO: 475150-69-7Molecular Formula: C27H35N3O2.2HClMolecular Weight: 506.51Purity: 98%Solubility: In

prudect name : BAN ORL 24 Synonyms: CAS NO: 475150-69-7Molecular Formula: C27H35N3O2.2HClMolecular Weight: 506.51Purity: 98%Solubility: In DMSOStorage: -20°C JQ-1 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503748

📌

0💬 read more

VD/VDR- vd-vdr

Posts by VD/VDR- vd-vdr