VD/VDR- vd-vdr

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Posts by VD/VDR- vd-vdr

prudect name : BoceprevirSynonyms: CAS NO: 394730-60-0Molecular Formula: C27H45N5O5Molecular Weight: 519.68Purity: 98% minSolubility: In DMSOStorage:

 June 21, 2017

prudect name : Boceprevir Synonyms: CAS NO: 394730-60-0Molecular Formula: C27H45N5O5Molecular Weight: 519.68Purity: 98% minSolubility: In DMSOStorage: -20°C 191732-72-6 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503256

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prudect name : beta-Estradiol semihydrateSynonyms: CAS NO: 35380-71-3Molecular Formula: 2(C18H24O2).H2OMolecular Weight: 562.79Purity: 98% minSolubility: Storage:

prudect name : beta-Estradiol semihydrate Synonyms: CAS NO: 35380-71-3Molecular Formula: 2(C18H24O2).H2OMolecular Weight: 562.79Purity: 98% minSolubility: Storage: −20°C 915019-65-7 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503218

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BMS-708163 (Avagacestat) is a potent and selective ¦Ã-secretase inhibitor (GSI) (IC50 =0.3 nM).

prudect name : BMS-708163 (Avagacestat) is a potent and selective ¦Ã-secretase inhibitor (GSI) (IC50 =0.3 nM).BMS-708163 (Avagacestat) Synonyms: CAS NO: 1146699-66-2Molecular Formula: C20H17ClF4N4O4SMolecular Weight: 520.89Purity: 98% minSolubility: In DMSOStorage: −20°C…

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Brivanib (BMS-540215) is hydrolyzed to the active moiety BMS-540215 in vivo. BMS-540215 shows potent and selective inhibition of VEGFR and FGFR tyrosine kinases . BMS-540215 is an ATP-competitive inhibitor of human VEGFR -2, with an IC50 of 25 nmol/L and Ki of 26 nmol/L. In addition, it inhibits VEGFR-1 (IC50 = 380 nmol/L) and VEGFR-3 (IC50 = 10 nmol/L). [1] BMS-540215 also showed good selectivity for FGFR-1 (IC50 = 148 nmol/L), FGFR-2 (IC50 =125 nmol/L), and FGFR-3 (IC50 = 68 nmol/L). Furthermore, BMS-540215 has been shown to selectively inhibit the proliferation of endothelial cells stimulated by VEGF and FGF in vitro with IC50 values of 40 and 276 nmol/L, respectively

prudect name : Brivanib (BMS-540215) is hydrolyzed to the active moiety BMS-540215 in vivo. BMS-540215 shows potent and selective inhibition of VEGFR and FGFR tyrosine kinases . BMS-540215 is an…

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prudect name : Baricitinib INCB 028050 LY3009104Synonyms: Baricitinib INCB 028050 LY3009104CAS NO: 1187594-09-7Molecular Formula: C16H17N7O2SMolecular

prudect name : Baricitinib INCB 028050 LY3009104 Synonyms: Baricitinib INCB 028050 LY3009104CAS NO: 1187594-09-7Molecular Formula: C16H17N7O2SMolecular Weight: 371.42Purity: 98% minSolubility: In DMSOStorage: -20°C 606143-89-9 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503093

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BMS-794833,a potent ATPcompetitive Met/VEGFR-2 kinase inhibitor,demonstrates enhanced activity versus both Met-dependent and Met-insensitive tumor lines. BMS-794833 also inhibits Ron (Met family),Axl (phylogenetically related Axl/Tyro3/Mer subfamily) and Flt-3 with IC50 values <3 nM. The compound was selective versus a panel of >200 additional RTKs, non-RTKs and serine/threonine kinases based on biochemical or Ambit binding assays. In cell culture, BMS-794833 inhibited the proliferation of human tumor cell lines containing constitutively activated Met receptor (GTL-16 gastric carcinoma). Tumor cell lines whose growth is stimulated by HGF (U87 glioblastoma) were also effectively inhibited by BMS-794833. In vivo, BMS-794833 demonstrated dose-dependent tumor growth inhibition following oral administration in the GTL-16 and L2987 lung carcinoma (Met-insensitive) xenograft models. Despite the impressive antitumor activity, BMS-794833 showed dissolution rate-limited absorption from solid dosage forms.

prudect name : BMS-794833,a potent ATPcompetitive Met/VEGFR-2 kinase inhibitor,demonstrates enhanced activity versus both Met-dependent and Met-insensitive tumor lines. BMS-794833 also inhibits Ron (Met family),Axl (phylogenetically related Axl/Tyro3/Mer subfamily) and Flt-3…

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BMS-582664 inhibits VEGF-stimulated and FGF-stimulated proliferating of HUVECs with IC50 of 40 nM and 276 nM. BMS-582664 (2 ¦ÌM) significantly inhibits VEGFR2, FGFR1, ERK1/2 and Akt phosphorylation in VEGF- and bFGF-stimulated SK-HEP1 cells and HepG-2 cells, while BMS-582664 alone has little effect on levels of phosphorylated ERK1/2, Akt, VEGFR2, and FGFR1 in nonstimulated cells. BMS-582664 inhibits CYP2C19, CYP3A4(BFC) and CYP3A4 (BzRes) with IC50 of 2.4 ¦ÌM, 0.51 ¦ÌM and 1.6 ¦ÌM, respectively. BMS-582664 exhibits high solid state stability (only 0.3% degradation at 50¡æ with desiccant over a period of 12 weeks) and acceptable solution state stability up to pH 6.5.

prudect name : BMS-582664 inhibits VEGF-stimulated and FGF-stimulated proliferating of HUVECs with IC50 of 40 nM and 276 nM. BMS-582664 (2 ¦ÌM) significantly inhibits VEGFR2, FGFR1, ERK1/2 and Akt phosphorylation…

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Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains.

prudect name : Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis…

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ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 ¦ÌM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 ¦ÌM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 ¦ÌM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia. Orally bioavailable.

prudect name : ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 ¦ÌM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 ¦ÌM in HepG2 cells). Displays no cytotoxicity up…

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Tubulin polymerization inhibitors, anti-angiogenic cancer drugs

prudect name : Tubulin polymerization inhibitors, anti-angiogenic cancer drugsBNC105P Synonyms: CAS NO: 945771-96-0Molecular Formula: C20H19Na2O10PMolecular Weight: 496.31Purity: 98% minSolubility: In DMSOStorage: -20°C 1005491-05-3 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502996

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