prudect name : Amiodarone hydrochlorideSynonyms: CAS NO: 199774-82-4Molecular Formula: C25H29I2NO3.ClHMolecular Weight: 681.77Purity: 99%Solubility: In DMSOStorage:

June 21, 2017

prudect name : Amiodarone hydrochloride Synonyms: CAS NO: 199774-82-4Molecular Formula: C25H29I2NO3.ClHMolecular Weight: 681.77Purity: 99%Solubility: In DMSOStorage: −20°C 2 years 174022-42-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502705

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A-796260 is a synthetic cannabinoid (CB) that shows high selectivity for the CB2 receptor (Ki = 0.77 nM) over the CB1 receptor (Ki = 2,100 nM).

prudect name : A-796260 is a synthetic cannabinoid (CB) that shows high selectivity for the CB2 receptor (Ki = 0.77 nM) over the CB1 receptor (Ki = 2,100 nM).A 796260…

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prudect name : AzatadinemaleateSynonyms: CAS NO: 3978-86-7Molecular Formula: C28H30N2O8Molecular Weight: 522.551Purity: 99%Solubility: Storage: −20°C

prudect name : Azatadinemaleate Synonyms: CAS NO: 3978-86-7Molecular Formula: C28H30N2O8Molecular Weight: 522.551Purity: 99%Solubility: Storage: −20°C 2 years 33069-62-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502659

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AST1306 is a novel anilino-quinazoline compound, which inhibits the enzymatic activities of wild-type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. AST1306 was found to function as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. In vivo, AST1306 potently suppressed tumor growth in ErbB2-overexpressing adenocarcinoma xenograft and FVB-2/N(neu) transgenic breast cancer mouse models, but weakly inhibited the growth of EGFR-overexpressing tumor xenografts. Tumor growth inhibition induced by a single dose of AST1306 in the SK-OV-3 xenograft model was accompanied by a rapid (within 2 h) and sustained (≥24 h) inhibition of both EGFR and ErbB2, consistent with an irreversible inhibition mechanism. Taken together, these results establish AST1306 as a selective, irreversible ErbB2 and EGFR inhibitor whose growth-inhibitory effects are more potent in ErbB2-overexpressing cells.

prudect name : AST1306 is a novel anilino-quinazoline compound, which inhibits the enzymatic activities of wild-type epidermal growth factor receptor (EGFR) and ErbB2 as well as EGFR resistant mutant in…

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prudect name : alpha,alpha-Diphenyl-4-piperidinomethanolSynonyms: CAS NO: 115-46-8Molecular Formula: C18H21NOMolecular Weight: 267.37Purity: 99%Solubility: Storage: −20°C

prudect name : alpha,alpha-Diphenyl-4-piperidinomethanol Synonyms: CAS NO: 115-46-8Molecular Formula: C18H21NOMolecular Weight: 267.37Purity: 99%Solubility: Storage: −20°C 2 years 2450-53-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502589

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Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy.

prudect name : Andarine (S-4) is an investigational selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy.Andarine (GTx-007) Synonyms: CAS NO:…

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ABT-737 shows low activity to Bcl-B and no effects to Mcl-1 and BFL-1. ABT-737 is sensitive to HL60, KG1 and NB4 cells with IC50 of 50 nM, 80 nM and 80 nM, respectively. ABT-737 induces apoptosis in HL60 cells, which due to decreased Bcl-2/Bax heterodimerization and has no effect on cell cycle distribution. ABT-737 also induces cytochrome c release from purified mitochondria and promotes conformational changes in Bax that are associated with apoptosis.

prudect name : ABT-737 shows low activity to Bcl-B and no effects to Mcl-1 and BFL-1. ABT-737 is sensitive to HL60, KG1 and NB4 cells with IC50 of 50 nM,…

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Anacetrapib is not only able to increase HDL-cholesterol, but also further decreases LDL-cholesterol when taken in combination with a statin. Anacetrapib dose-dependently and significantly decreases the transfer of CE from HDL3 to HDL2. Anacetrapib doesn¡¯t affect the amount of [14C]-dalcetrapibthiol bound to rhCETP. Anacetrapib decreases pre-¦Â-HDL formation by more than 46%.Anacetrapib potently blocks CE and TG transfer in 95% human serum.

prudect name : Anacetrapib is not only able to increase HDL-cholesterol, but also further decreases LDL-cholesterol when taken in combination with a statin. Anacetrapib dose-dependently and significantly decreases the transfer…

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prudect name : AzathioprineSynonyms: CAS NO: 446-86-6Molecular Formula: C9H7N7O2SMolecular Weight: 277.26Purity: 99%Solubility: Storage: −20°C

prudect name : Azathioprine Synonyms: CAS NO: 446-86-6Molecular Formula: C9H7N7O2SMolecular Weight: 277.26Purity: 99%Solubility: Storage: −20°C 2 years 129-56-6 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18502492

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AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation and induced apoptosis in a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects in vitro and in vivo. Antitumor efficacy in HER2-positive, PIK3CA-mutant BT474 breast, PTEN-deficient PC3 human prostate cancer, and PTEN-deficient MES-SA uterine tumor xenografts was shown. We show for the first time that induction of AKT phosphorylation at serine 473 by AT13148, as reported for other ATP-competitive inhibitors of AKT, is not a therapeutically relevant reactivation step. Gene expression studies showed that AT13148 has a predominant effect on apoptosis genes, whereas the selective AKT inhibitor CCT128930 modulates cell-cycle genes. Induction of upstream regulators including IRS2 and PIK3IP1 as a result of compensatory feedback loops was observed.

prudect name : AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK, and SGK substrate phosphorylation and induced apoptosis in a concentration and time-dependent manner in cancer cells with clinically…

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