AZD8186 potently inhibits p-Akt in MDA-MB-468 cells sensitive to PI3K¦Â inhibition and Jeko B cells sensitive to PI3K¦Ä inhibition with IC50 of 3 nM and 4 nM, respectively. AZD8186 shows preferred growth inhibition activity in most PTEN deficient cell lines with GI50 of <1 ¦ÌM.

June 21, 2017

prudect name : AZD8186 potently inhibits p-Akt in MDA-MB-468 cells sensitive to PI3K¦Â inhibition and Jeko B cells sensitive to PI3K¦Ä inhibition with IC50 of 3 nM and 4 nM,…

📌

0💬 read more

Potent and selective tyrosine kinase (Trk) inhibitor with IC50 to 2 and 8 nM for TrkA and TrkB respectively; AZ-23 showed in vivo TrkA kinase inhibition and efficacy in mice following oral administration; having potential for therapeutic utility in neuroblastoma and multiple other cancer indications.

prudect name : Potent and selective tyrosine kinase (Trk) inhibitor with IC50 to 2 and 8 nM for TrkA and TrkB respectively; AZ-23 showed in vivo TrkA kinase inhibition and…

📌

0💬 read more

prudect name : Atosiban AcetateSynonyms: CAS NO: 90779-69-4Molecular Formula: C43H67N11O12S2Molecular Weight: 994.19Purity: 98% minSolubility: Storage:

prudect name : Atosiban Acetate Synonyms: CAS NO: 90779-69-4Molecular Formula: C43H67N11O12S2Molecular Weight: 994.19Purity: 98% minSolubility: Storage: -20°C 1219168-18-9 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18499565

📌

0💬 read more

Ambrisentan is a novel highly selective endothelin receptor antagonist for the treatment of pulmonary arterial hypertension.

prudect name : Ambrisentan is a novel highly selective endothelin receptor antagonist for the treatment of pulmonary arterial hypertension.Ambrisentan Synonyms: CAS NO: 177036-94-1Molecular Formula: C22H22N2O4Molecular Weight: 378.43Purity: ≥99%Solubility: Storage: −20°C…

📌

0💬 read more

AMG 458 also inhibits HGF-mediated c-Met phosphorylation in PC3 and CT26 cells with IC50 of 60 and 120 nM.AMG 458 is observed to bind covalently to liver microsomal proteins from rats and humans in the absence of NADPH. AMG 458 is believed to react with thiol groups in proteins, producing a methoxy quinoline thioether conjugate.A recent study shows that the constitutive phosphorylation of c-Met in H441 is abrogated by AMG 458. The basal and HGF-induced phosphorylation of c-Met in A549 is attenuated by AMG 458. The combination of radiation therapy and AMG 458 treatment is found to synergistically increase apoptosis in the H441 cell line by reduction of p-Akt and p-Erk levels, but not in A549.

prudect name : AMG 458 also inhibits HGF-mediated c-Met phosphorylation in PC3 and CT26 cells with IC50 of 60 and 120 nM.AMG 458 is observed to bind covalently to liver…

📌

0💬 read more

prudect name : AdapaleneSynonyms: CAS NO: 106685-40-9Molecular Formula: C28H28O3Molecular Weight: 412.52Purity: 99%Solubility: Storage: −20°C

prudect name : Adapalene Synonyms: CAS NO: 106685-40-9Molecular Formula: C28H28O3Molecular Weight: 412.52Purity: 99%Solubility: Storage: −20°C 2 years 187227-45-8 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18499400

📌

0💬 read more

[4-[[5-Fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-2-pyrimidinyl]amino]phenyl][(3S)-3-(methylamino)-1-pyrrolidinyl]methanone

prudect name : [4-[[5-Fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-2-pyrimidinyl]amino]phenyl][(3S)-3-(methylamino)-1-pyrrolidinyl]methanoneAZD 5597 Synonyms: CAS NO: 924641-59-8Molecular Formula: C23H28FN7OMolecular Weight: 437.51Purity: 98% minSolubility: In DMSOStorage: -20 oC 501437-28-1 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18499397

📌

0💬 read more

Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

prudect name : Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of

📌

0💬 read more

prudect name : Azlocillin sodiumSynonyms: CAS NO: 37091-65-9Molecular Formula: C20H22N5NaO6SMolecular Weight: 483.47Purity: ≥99%Solubility: Storage: −20°C

prudect name : Azlocillin sodium Synonyms: CAS NO: 37091-65-9Molecular Formula: C20H22N5NaO6SMolecular Weight: 483.47Purity: ≥99%Solubility: Storage: −20°C 2 years 648903-57-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1849926

📌

0💬 read more

prudect name : AzlocillinSynonyms: CAS NO: 37091-66-0Molecular Formula: C20H23N5O6SMolecular Weight: 461.49Purity: ≥99%Solubility: Storage: −20°C

prudect name : Azlocillin Synonyms: CAS NO: 37091-66-0Molecular Formula: C20H23N5O6SMolecular Weight: 461.49Purity: ≥99%Solubility: Storage: −20°C 2 years 377727-87-2 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18499213

📌

0💬 read more

VD/VDR- vd-vdr

Posts by VD/VDR- vd-vdr