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This product is synthesis of vinblastine sulfate, vinorelbine, vinblastine and other raw materials for dehydration.

June 21, 2017

prudect name : This product is synthesis of vinblastine sulfate, vinorelbine, vinblastine and other raw materials for dehydration.Vindoline Synonyms: CAS NO: 2182-14-1Molecular Formula: C25H32N2O6Molecular Weight: 456.54Purity: 99%Solubility: In DMSOStorage: −20°C…

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prudect name : Vindesine sulfateSynonyms: Desacetylvinblastine amide sulfate (1:1)CAS NO: 59917-39-4Molecular Formula: C43H55N5O7.H2SO4Molecular Weight: 852.01Purity:

prudect name : Vindesine sulfate Synonyms: Desacetylvinblastine amide sulfate (1:1)CAS NO: 59917-39-4Molecular Formula: C43H55N5O7.H2SO4Molecular Weight: 852.01Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4¡À1.1, 28.1¡À3.4, 22.4¡À2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism.

prudect name : Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4¡À1.1, 28.1¡À3.4, 22.4¡À2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of…

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prudect name : VinpocetineSynonyms: CAS NO: 42971-09-5Molecular Formula: C22H26N2O2Molecular Weight: 350.45Purity: 99%Solubility: Storage: −20°C

prudect name : Vinpocetine Synonyms: CAS NO: 42971-09-5Molecular Formula: C22H26N2O2Molecular Weight: 350.45Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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Vinflunine exerts marked cytotoxicity against a selected panel of nine human solid tumor cell lines of different origins (colon, prostate, bladder, breast, and ovary) with IC50 values ranging from 27 nmol/L to 14 umol/L.Vinflunine, at the lowest effective concentrations, interacts with the Vinca alkaloid binding site on tubulin, suppresses microtubule dynamics (switching at microtubule ends between phases of slow growth and rapid shortening) and microtubule treadmilling (growth at the plus end and shortening at the minus end of the microtubule), causes cell cycle arrest which appears on fluorescence-activated cell sorting analysis as a G2 + M phase arrest, and is associated with an accumulation of cells in mitosis[2] leading to cell death via apoptosis.[3] In vitro vinflunine cytotoxicity proved dependent on concentration and exposure duration, with IC50 values (72-hr exposures) generally ranging from 60-300 nM. Vinflunine induced G2 + M arrest, associated with mitotic accumulation and a concentration-dependent reduction of the microtubular network of interphase cells, accompanied by paracrystal formation.

prudect name : Vinflunine exerts marked cytotoxicity against a selected panel of nine human solid tumor cell lines of different origins (colon, prostate, bladder, breast, and ovary) with IC50 values…

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prudect name : Vinblastine sulfateSynonyms: Vincaleukoblastine sulfate saltCAS NO: 143-67-9Molecular Formula: C46H58N4O9.H2SO4Molecular Weight: 909.06Purity: 99%Solubility:

prudect name : Vinblastine sulfate Synonyms: Vincaleukoblastine sulfate saltCAS NO: 143-67-9Molecular Formula: C46H58N4O9.H2SO4Molecular Weight: 909.06Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com

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Vinorelbine (Navelbine) is an anti-mitotic, semisynthetic derivative of vinca alkaloid which inhibits the proliferation of Hela cells with an IC50 of 1.25 nM.

prudect name : Vinorelbine (Navelbine) is an anti-mitotic, semisynthetic derivative of vinca alkaloid which inhibits the proliferation of Hela cells with an IC50 of 1.25 nM.Vinorelbine tartrate Synonyms: CAS NO:…

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Vildagliptin is an anti-diabetic drug

prudect name : Vildagliptin is an anti-diabetic drugVildagliptin Synonyms: CAS NO: 274901-16-5Molecular Formula: C17H25N3O2Molecular Weight: 303.40Purity: 99%Solubility: In DMSOStorage: −20°C web site: www.medchemexpress.com

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VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3 _mu_M).

prudect name : VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50…

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Suberoylanilide hydroxamic acid (SAHA). Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by histone deacetylase (HDAC). HDAC inhibitors can block cancer cell growth by restoring expression of tumor suppressor genes. Vorinostat efficiently suppressed MES-SA cell growth at a low dosage (3 ¦ÌM) already after 24 hours treatment. Decrease of cell survival was even more pronounced after prolonged treatment and reached 9% and 2% after 48 and 72 hours of treatment, respectively. Colony forming capability of MES-SA cells treated with 3 ¦ÌM vorinostat for 24 and 48 hours was significantly diminished and blocked after 72 hours

prudect name : Suberoylanilide hydroxamic acid (SAHA). Tumor suppressor genes are often silenced in human cancer; this can occur by transcriptional repression by deacetylation in the promoter regions, mediated by…

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