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Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.

June 21, 2017

prudect name : Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin…

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Plerixafor inhibits CXCL12-mediated chemotaxis with a potency slightly better than its affinity for CXCR4.Plerixafor also antagonizes SDF-1/CXCL12 ligand binding with an IC50 of 651 nM. Plerixafor inhibits SDF-1 mediated GTP-binding, SDF-1 mediated calcium flux and SDF-1 stimulated chemotaxis with IC50 of 27 nM, 572 nM and 51 nM, respectively. Plerixafor does not inhibit calcium flux against cells expressing CXCR3, CCR1, CCR2b, CCR4, CCR5 or CCR7 when stimulated with their cognate ligands, Nor does Plerixafor inhibit receptor binding of LTB4. Plerixafor does not, on its own, induce a calcium flux in the CCRF¨CCEM cells, which express multiple GPCRs including CXCR4, CCR4 and CCR7.

prudect name : Plerixafor inhibits CXCL12-mediated chemotaxis with a potency slightly better than its affinity for CXCR4.Plerixafor also antagonizes SDF-1/CXCL12 ligand binding with an IC50 of 651 nM. Plerixafor inhibits…

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Prucalopride short-term treatment of severe chronic constipation can significantly improve bowel function, reduce symptoms of constipation.

prudect name : Prucalopride short-term treatment of severe chronic constipation can significantly improve bowel function, reduce symptoms of constipation.Prucalopride Synonyms: CAS NO: 179474-81-8Molecular Formula: C18H26ClN3O3Molecular Weight: 367.8744Purity: 99%Solubility: In DMSOStorage:…

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Ruxolitinib_Intermediates

prudect name : Ruxolitinib_IntermediatesPyrazole-4-boronic acid pinacol ester Synonyms: CAS NO: 269410-08-4Molecular Formula: C9H15BN2O2Molecular Weight: 194.04Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397. PND-1186 did not alter c Src or p130Cas tyrosine phosphorylation in adherent cells, yet functioned to restrain cell movement. Notably, 1.0 ?M PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 ?M PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis

prudect name : PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397. PND-1186 did not alter c Src or p130Cas…

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Pimecrolimus caused a strong and dose-dependent inhibition of anti-IgE¨Cinduced release of histamine from mast cells and basophils (maximally 73% and 82%, respectively, at 500 nmol/L pimecrolimus) and of mast cell tryptase (maximally 75%) and a less pronounced inhibition of LTC4 (maximally 32%) and of calcium ionophore plus phorbol myristate acetate¨Cinduced mast cell TNF-¦Á release (90% maximum at 100 nmol/L pimecrolimus).

prudect name : Pimecrolimus caused a strong and dose-dependent inhibition of anti-IgE¨Cinduced release of histamine from mast cells and basophils (maximally 73% and 82%, respectively, at 500 nmol/L pimecrolimus) and…

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PD 184352/CI-1040 is a non-competitive inhibitor of MEK1/2 with a Ki of 300nM in vitro CI-1040 inhibited MEK (as measured by phosphorylated ERK (p-ERK) levels) with a half-maximal inhibitory concentration (IC50) of 100¨C500nM in all cell lines tested

prudect name : PD 184352/CI-1040 is a non-competitive inhibitor of MEK1/2 with a Ki of 300nM in vitro CI-1040 inhibited MEK (as measured by phosphorylated ERK (p-ERK) levels) with a…

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PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM.PH-797804 reversibly inhibits the alpha isoform of human p38 MAP kinase with a Ki of 5.8 nM.Additionally, in a human peripheral blood monocyte assay, PH-797804 inhibits hPBMC TNF, exhibiting IC50 of 3.4 nM. Indeed, PH-797804 revealed exceptionally high specificity against MAP kinases and the related kinases. In cellular assays, PH-797804 demonstrated superior potency and selectivity in good line with the biochemical measurements.

prudect name : PH-797804 is a highly selective, potent, and ATP-competitive p38 MAP kinase inhibitor with an IC50 of 2.3 nM.PH-797804 reversibly inhibits the alpha isoform of human p38 MAP…

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I-3065 is a novel potent and selective PI3K p110¦Ä inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110¦Á, p110¦Â, p110¦Ã, DNA-PK and mTOR.

prudect name : I-3065 is a novel potent and selective PI3K p110¦Ä inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110¦Á, p110¦Â, p110¦Ã, DNA-PK and mTOR.PI-3065…

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1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-ol

prudect name : 1-(3,6-Dibromo-carbazol-9-yl)-3-phenylamino-propan-2-olP7C3 Synonyms: CAS NO: 301353-96-8Molecular Formula: C21H18Br2N2OMolecular Weight: 474.21Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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