OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays

 June 21, 2017

prudect name : OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assaysOTX015 Synonyms: CAS NO: 202590-98-5Molecular…

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Corrigen; Foliandrin; Folinerin; Neriol; Neriolin; Neriostene; (3beta,5beta,16beta)-16-(Acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide

prudect name : Corrigen; Foliandrin; Folinerin; Neriol; Neriolin; Neriostene; (3beta,5beta,16beta)-16-(Acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolideOleandrin Synonyms: CAS NO: 465-16-7Molecular Formula: C32H48O9Molecular Weight: 576.72Purity: 98% minSolubility: DMSOStorage: -20ยกรฆ web site: www.medchemexpress.com References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18538731

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Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a significant decrease in specific binding of CB1 receptor inverse agonist SR141716A (Rimonabant; pKB = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pKB = 7.57 at CB1 receptors in mouse vas deferens.

prudect name : Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a…

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Olanzapine is an atypical antipsychotic drug for the treatment of positive symptoms of schizophrenia, but also some effect on negative symptoms.

prudect name : Olanzapine is an atypical antipsychotic drug for the treatment of positive symptoms of schizophrenia, but also some effect on negative symptoms.Olanzapine Synonyms: CAS NO: 132539-06-1Molecular Formula: C17H20N4SMolecular…

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OC000459 is a once-daily oral CRTH2 antagonist in Phase IIb clinical trials that has demonstrated efficacy in asthma, allergic rhinitis and allergic conjunctivitis along with an excellent safety profile.

prudect name : OC000459 is a once-daily oral CRTH2 antagonist in Phase IIb clinical trials that has demonstrated efficacy in asthma, allergic rhinitis and allergic conjunctivitis along with an excellent…

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prudect name : OzagrelSynonyms: CAS NO: 82571-53-7Molecular Formula: C13H12N2O2Molecular Weight: 228.25Purity: 99%Solubility: Storage: −20°C 2

prudect name : Ozagrel Synonyms: CAS NO: 82571-53-7Molecular Formula: C13H12N2O2Molecular Weight: 228.25Purity: 99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18538524

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prudect name : Oclacitinib PF-03394197Synonyms: CAS NO: 1208319-26-9Molecular Formula: C15H23N5O2S Molecular Weight: 337.44 Purity: 98%

prudect name : Oclacitinib PF-03394197 Synonyms: CAS NO: 1208319-26-9Molecular Formula: C15H23N5O2S Molecular Weight: 337.44 Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18538505

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prudect name : oritavancin,LY333328 phosphate saltSynonyms: CAS NO: 171099-57-3 192564-14-0(phosphate salt)Molecular Formula: C86H97Cl3N10O26Molecular Weight: 1793.115Purity:

prudect name : oritavancin,LY333328 phosphate salt Synonyms: CAS NO: 171099-57-3 192564-14-0(phosphate salt)Molecular Formula: C86H97Cl3N10O26Molecular Weight: 1793.115Purity: 95% minSolubility: in DMSOStorage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18538407

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1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone

prudect name : 1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanoneOTSSP167 Synonyms: CAS NO: 1431697-89-0Molecular Formula: C25H28Cl2N4O2Molecular Weight: 487.42Purity: 98% minSolubility: In DMSOStorage: -20 oC web site: www.medchemexpress.com References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18538404

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Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption.

prudect name : Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a…

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