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OSU-03012 is a recently licensed novel derivative of the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CelebrexTM); however, it lacks COX-2 inhibitory activity. It potently induces apoptosis in several types of cancer cells.The mechanism is mediated, at least in part, through the inhibition of phosphoinositide-dependent kinase-1 (PDK-1), an upstream kinase that phosphorylates AKT.OSU-03012 inhibited cell proliferation more effectively in both VS (IC50=3.1 ¦ÌM ) and HMS-97 (IC50=2.6 ¦ÌM )cells than in normal human Schwann cells(IC50=12 ¦ÌM ). OSU-03012 was well tolerated and inhibited the growth of HMS-97 schwannoma xenografts by 55% after 9 weeks of oral treatment. The anti-tumour activity correlated with reduced AKT phosphorylation

June 21, 2017

prudect name : OSU-03012 is a recently licensed novel derivative of the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CelebrexTM); however, it lacks COX-2 inhibitory activity. It potently induces apoptosis in several types…

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Oprozomib is demonstrated an absolute bioavailability of up to 39% in rodents and dogs. It is well tolerated with repeated oral administration at doses resulting in >80% proteasome inhibition in most tissues and elicited an antitumor response in multiple human tumor xenograft and mouse syngeneic models

prudect name : Oprozomib is demonstrated an absolute bioavailability of up to 39% in rodents and dogs. It is well tolerated with repeated oral administration at doses resulting in >80%…

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ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.

prudect name : ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.ODM-201 Synonyms: CAS NO: 1297538-32-9Molecular…

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prudect name : Oclacitinib maleateSynonyms: CAS NO: 1208319-27-0Molecular Formula: C15H23N5O2SC4H4O4Molecular Weight: 453.5173Purity: 98% minSolubility: in

prudect name : Oclacitinib maleate Synonyms: CAS NO: 1208319-27-0Molecular Formula: C15H23N5O2SC4H4O4Molecular Weight: 453.5173Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538294

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prudect name : Oligomycin ASynonyms: CAS NO: 579-13-5Molecular Formula: C45H74O11Molecular Weight: 791.06Purity: 98% minSolubility: In

prudect name : Oligomycin A Synonyms: CAS NO: 579-13-5Molecular Formula: C45H74O11Molecular Weight: 791.06Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538271

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prudect name : OrnoprostilSynonyms: CAS NO: 70667-26-4Molecular Formula: C23H38O6Molecular Weight: 410.54Purity: 98% minSolubility: Storage: -20°C

prudect name : Ornoprostil Synonyms: CAS NO: 70667-26-4Molecular Formula: C23H38O6Molecular Weight: 410.54Purity: 98% minSolubility: Storage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538263

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prudect name : Oxytocin AcetateSynonyms: CAS NO: 50-56-6Molecular Formula: C43H66N12O12S2Molecular Weight: 1007.19Purity: 98% minSolubility: Storage:

prudect name : Oxytocin Acetate Synonyms: CAS NO: 50-56-6Molecular Formula: C43H66N12O12S2Molecular Weight: 1007.19Purity: 98% minSolubility: Storage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538144

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L-Arginine, L-glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-; L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-arginin

prudect name : L-Arginine, L-glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-; L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-argininopiorphin ; H-6504 Synonyms: CAS NO: 864084-88-8Molecular Formula: C29H48N12O8Molecular Weight: 692.77Purity: 98% minSolubility: Storage: -20 oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538094

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prudect name : osi-420Synonyms: CAS NO: 183321-86-0Molecular Formula: C21H21N3O4Molecular Weight: 379.41Purity: 98% minSolubility: In DMSOStorage:

prudect name : osi-420 Synonyms: CAS NO: 183321-86-0Molecular Formula: C21H21N3O4Molecular Weight: 379.41Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18538012

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Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. It is intended for use in conjunction with a physician-supervised reduced-calorie diet. Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. However, due to simplicity and stability, orlistat rather than lipstatin was developed into an anti-obesity drug.

prudect name : Orlistat is a drug that promotes loss of weight by preventing the digestion and absorption of fat in food. It is intended for use in conjunction with…

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