VD/VDR-vd-vdr.com

NVP-BGT226 has entered phase I/II clinical trials for the treatment of advanced solid tumors (including breast cancer).

June 21, 2017

prudect name : NVP-BGT226 has entered phase I/II clinical trials for the treatment of advanced solid tumors (including breast cancer).NVP-BGT226 Synonyms: CAS NO: 1245537-68-1Molecular Formula: C28H25F3N6O2.C4H4O4Molecular Weight: 650.6Purity: 98% minSolubility:…

📌

0💬 read more

prudect name : NorethindroneSynonyms: CAS NO: 68-22-4Molecular Formula: C20H26O2Molecular Weight: 298.42Purity: 99% minSolubility: Storage: −20°C

prudect name : Norethindrone Synonyms: CAS NO: 68-22-4Molecular Formula: C20H26O2Molecular Weight: 298.42Purity: 99% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536938

📌

0💬 read more

NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM. NVP-BVU972 also suppresses constitutive MET phosphorylation in GTL-16 cells or HGF-stimulated MET phosphorylation in A549 cells with IC50 values of 7.3 nM and 22 nM, respectively. NVP-BVU972 potently prevents the growth of the MET gene amplified cell linse GTL-16, MKN-45 and EBC-1 with IC50 values of 66 nM, 82 nM and 32 nM, respectively. In line with their high frequency in the NVP-BVU972 screen, Y1230 and D1228 mutations give rise to dramatic shifts in the measured IC50 values for NVP-BVU972 in BaF3 cell line. Resistance triggered by V1155L is more limited to NVP-BVU972.A dose-dependent reduction in TPR-MET phosphorylation when applying NVP-BVU972 to BaF3 cells expressing wild-type TPR-MET. Both Y1230H and D1228A mutations abrogated the effect of NVP-BVU972. However, F1200I and L1195V interferes with the potency of NVP-BVU972 to prevent TPR-MET phosphorylation.

prudect name : NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM….

📌

0💬 read more

MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.

prudect name : MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against…

📌

0💬 read more

prudect name : NSC-339555;BRYOSTATIN;BRYOSTATIN 1Synonyms: CAS NO: 83314-01-6Molecular Formula: C47H68O17Molecular Weight: 905.03Purity: 98% minSolubility: Storage:

prudect name : NSC-339555;BRYOSTATIN;BRYOSTATIN 1 Synonyms: CAS NO: 83314-01-6Molecular Formula: C47H68O17Molecular Weight: 905.03Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536718

📌

0💬 read more

is important fine organic chemical intermediates, widely used in medicine, chemical industry and other fields.

prudect name : is important fine organic chemical intermediates, widely used in medicine, chemical industry and other fields.N-(9-acetyl-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide Synonyms: 9-[(2-Acetoxyethoxy)methyl]-N2-acetylguanineCAS NO: 3056-33-5Molecular Formula: C9H9N5O3Molecular Weight: 235.20Purity: ≥98%Solubility: Storage: −20°C 2…

📌

0💬 read more

Vemurafenib intermediate

prudect name : Vemurafenib intermediateN-{3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-1-propanesulfonamide Synonyms: CAS NO: 918504-27-5Molecular Formula: C17H14BrF2N3O3SMolecular Weight: 458.28Purity: 98% minSolubility: Storage: web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536712

📌

0💬 read more

prudect name : NedocromilSynonyms: CAS NO: 69049-73-6Molecular Formula: C19H17NO7Molecular Weight: 371.35Purity: 98% minSolubility: In DMSOStorage:

prudect name : Nedocromil Synonyms: CAS NO: 69049-73-6Molecular Formula: C19H17NO7Molecular Weight: 371.35Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536657

📌

0💬 read more

NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. NPS 2143 stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC50 of 41 nM. Moreover, NPS 214 also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP formation.

prudect name : NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+…

📌

0💬 read more

prudect name : NorgestrelSynonyms: CAS NO: 6533-00-2Molecular Formula: C21H28O2Molecular Weight: 312.45Purity: 98% minSolubility: Storage: −20°C

prudect name : Norgestrel Synonyms: CAS NO: 6533-00-2Molecular Formula: C21H28O2Molecular Weight: 312.45Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536531

📌

0💬 read more