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prudect name : N,N’-Bis(naphthalene-2-yl)-N,N’-bis(phenyl)benzidineSynonyms: ¦Á-NPBCAS NO: 139255-17-7Molecular Formula: C44H32N2Molecular Weight: 588.74Purity: 99% minSolubility: Storage:

June 21, 2017

prudect name : N,N’-Bis(naphthalene-2-yl)-N,N’-bis(phenyl)benzidine Synonyms: ¦Á-NPBCAS NO: 139255-17-7Molecular Formula: C44H32N2Molecular Weight: 588.74Purity: 99% minSolubility: Storage: web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536375

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Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 ¦Ìmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in vivo. Displays no effect on the catalytic activity of MT1-MMP or MMP-2.

prudect name : Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 ¦Ìmol/L). Directly interacts with the hemopexin domain (PEX) of MT1-MMP, affecting homodimerization and repressing its pro-tumorigenic activity in…

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N6022 is a potent, selective, reversible, and efficacious S-nitrosoglutathione reductase (GSNOR) inhibitor and is currently undergoing clinical development for the treatment of acute asthma. GSNOR is a member of the alcohol dehydrogenase family (ADH) and regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO). Reduced levels of GSNO, as well as other nitrosothiols (SNOs), have been implicated in the pathogenesis of many diseases including those of the respiratory, cardiovascular, and gastrointestinal systems. Preservation of endogenous SNOs through GSNOR inhibition presents a novel therapeutic approach with broad applicability. N6022 was demonstrated efficacy in a mouse ovalbumin (OVA) model of asthma.

prudect name : N6022 is a potent, selective, reversible, and efficacious S-nitrosoglutathione reductase (GSNOR) inhibitor and is currently undergoing clinical development for the treatment of acute asthma. GSNOR is a…

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N-benzyl-2-(6-bromo-2-methylquinolin-4-yloxy)acetamide

prudect name : N-benzyl-2-(6-bromo-2-methylquinolin-4-yloxy)acetamideN-benzyl-2-(6-bromo-2-methylquinolin-4-yloxy)acetamide Synonyms: CAS NO: 1443139-14-7Molecular Formula: C19H17BrN2O2Molecular Weight: 384.0Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18536238

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Nelarabine(Arranon) is a chemotherapy drug used in T-cell acute lymphoblastic leukemia. Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity. Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. This drug performed growth inhibitory activity (IC50 = 1.61 µM) against MOLT-4 cells

prudect name : Nelarabine(Arranon) is a chemotherapy drug used in T-cell acute lymphoblastic leukemia. Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in…

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NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7¦ÌM, respectively. NVP-BHG712 inhibits multiple Eph receptor kinases. NVP-BHG712 inhibits VEGF driven angiogenesis. In a panel of more than 40 in vitro kinase assays, NVP-BHG712 showed excellent selectivity. Only c-raf, c-src and c-abl showed moderate inhibition as judged from our biochemical assays. In cell based assays ED50 for inhibition of EphB4 autophosphorylation was found to be 25 nM and thereby be roughly 200 fold more potent on EphB4 than on VEGFR2. NVP-BHG712 inhibited dose dependently VEGF stimulated tissue formation and vascularization in this model. Already at doses of daily 3 mg/kg p.o administration we observed signiﬁcant inhibition, and daily administration of 10 mg/kg/kg p.o. was sufﬁcient to reverse VEGF enhanced tissue formation and vessel growth

prudect name : NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7¦ÌM, respectively. NVP-BHG712 inhibits…

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Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.

prudect name : Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms.Nexturastat A Synonyms: CAS NO: 1403783-31-2Molecular Formula: C19H23N3O3Molecular…

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17-phenyl trinor PGE2 serinol amide (17-phenyl trinor PGE2-SA) is a stable analog of PGE2 2-glyceryl ester that has been modified to increase receptor binding affinity. The biological activity of 17-phenyl trinor PGE2-SA has not yet been determined.

prudect name : 17-phenyl trinor PGE2 serinol amide (17-phenyl trinor PGE2-SA) is a stable analog of PGE2 2-glyceryl ester that has been modified to increase receptor binding affinity. The biological…

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Naltrexone hydrochlorideis an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.

prudect name : Naltrexone hydrochlorideis an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.Naltrexone hydrochloride Synonyms: CAS NO: 16676-29-2Molecular Formula: C20H23NO4.HClMolecular Weight: 377.86Purity: 98%…

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NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM.

prudect name : NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM.NMS-873 Synonyms: CAS NO: 1418013-75-8Molecular Formula: C27H28N4O3S2Molecular Weight: 520.67Purity: 98% minSolubility: In DMSOStorage: -20 oC…

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