VD/VDR-vd-vdr.com

prudect name : Nepicastat hydrochloride RS 25560-197Synonyms: RS 25560-197CAS NO: 170151-24-3Molecular Formula: C14H15F2N3S.HClMolecular Weight:

June 21, 2017

prudect name : Nepicastat hydrochloride RS 25560-197 Synonyms: RS 25560-197CAS NO: 170151-24-3Molecular Formula: C14H15F2N3S.HClMolecular Weight: 331.81Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535736

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Lapatinib(CAS NO:231277-92-2)Intermediates

prudect name : Lapatinib(CAS NO:231277-92-2)IntermediatesN-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-iodoquinazolin-4-amine Synonyms: CAS NO: 231278-20-9Molecular Formula: C21H14ClFIN3OMolecular Weight: 505.71Purity: ≥98%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535660

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Nilvadipine for light, moderate and severe hypertension treatment.

prudect name : Nilvadipine for light, moderate and severe hypertension treatment.Nilvadipine Synonyms: CAS NO: 75530-68-6Molecular Formula: C19H19N3O6Molecular Weight: 385.38Purity: ≥99%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535623

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Afatinib intermediates

prudect name : Afatinib intermediatesN-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine Synonyms: (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amineCAS NO: 162012-67-1Molecular Formula: C14H7ClF2N4O2Molecular Weight: 336.68Purity: 98% minSolubility: Storage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535608

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prudect name : N-EthylmethylamineSynonyms: CAS NO: 624-78-2Molecular Formula: C3H9NMolecular Weight: 59.11Purity: 98% minSolubility: Storage: -20°C

prudect name : N-Ethylmethylamine Synonyms: CAS NO: 624-78-2Molecular Formula: C3H9NMolecular Weight: 59.11Purity: 98% minSolubility: Storage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535601

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N,N¡¯-Propylenedinicotinamide

prudect name : N,N¡¯-PropylenedinicotinamideNicaraven Synonyms: CAS NO: 79455-30-4Molecular Formula: C15H16N4O2Molecular Weight: 284.31Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535554

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prudect name : N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamideSynonyms: CAS NO: 253168-86-4Molecular Formula: C22H24N2O7SMolecular Weight: 460.5Purity: 98% minSolubility: Storage: -20

prudect name : N-[2-[1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide Synonyms: CAS NO: 253168-86-4Molecular Formula: C22H24N2O7SMolecular Weight: 460.5Purity: 98% minSolubility: Storage: -20 oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535548/

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Macitentan intermediates

prudect name : Macitentan intermediatesN-Propylsulfamide Synonyms: CAS NO: 147962-41-2Molecular Formula: C3H10N2O2SMolecular Weight: 138.19Purity: 98% minSolubility: Storage: web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18535548

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BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. BKM120 inhibits tumor proliferation and survival by blocking the phosphatidylinositol-3-kinase (PI3K) pathway. BKM120 has shown significant cell growth inhibition and induction of apoptosis in a variety of tumor cell lines as well as in animal models. BKM120 specifically inhibits class I PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway in an ATP-competitive manner, thereby inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate and activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.

prudect name : BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor. BKM120 inhibits tumor proliferation and survival by blocking the phosphatidylinositol-3-kinase (PI3K) pathway. BKM120…

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Nocodazole is a high-affinity ligand for the cancer-related kinases including Abl phosphorylated, c-Kit, BRAF, and MEK with Kd of 0.091 ¦ÌM, 1.6 ¦ÌM, 1.8 ¦ÌM and 1.6 ¦ÌM, respectively. In addition, the Kd of Nocodazole for Abl(E255K) phosphorylated, Abl(T315I) phosphorylated, BRAF(V600E) and PI3K¦Ã is 0.12 ¦ÌM, 0.17 ¦ÌM, 1.1 ¦ÌM and 1.5 ¦ÌM, respectively. Nocodazole induces apoptosis in chronic lymphocytic leukemia cells. Nocodazole inhibits insulin-stimulated glucose transport. Nocodazole decreases apoptosis in some human colon carcinoma cells. Nocodazole impairs the morphology and directionality of migrating medial gan-glionic eminence cells.

prudect name : Nocodazole is a high-affinity ligand for the cancer-related kinases including Abl phosphorylated, c-Kit, BRAF, and MEK with Kd of 0.091 ¦ÌM, 1.6 ¦ÌM, 1.8 ¦ÌM and 1.6…

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