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Imatinib(CAS NO:152459-95-5)Intermediates

June 21, 2017

prudect name : Imatinib(CAS NO:152459-95-5)IntermediatesN-(5-amino-2-methylphenl)-4-(3-pyridyl)-2-pyrimidine-amine Synonyms: CAS NO: 152460-10-1Molecular Formula: C16H15N5Molecular Weight: 277.32Purity: ≥98%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18534960

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Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.

prudect name : Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional…

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Nemorubicin(Methoxymorpholinyl doxorubicin; MMDX; PNU 152243) is a 3¡¯-deamino-3¡¯[2-(S)-methoxy-4-morpholinyl]derivative of doxorubicin, Nemorubici has the anticancer activity on human hepatocellular carcinoma with an IC50 of 80 nM.

prudect name : Nemorubicin(Methoxymorpholinyl doxorubicin; MMDX; PNU 152243) is a 3¡¯-deamino-3¡¯[2-(S)-methoxy-4-morpholinyl]derivative of doxorubicin, Nemorubici has the anticancer activity on human hepatocellular carcinoma with an IC50 of 80 nM.Nemorubicin Synonyms: CAS…

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N-benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamide

prudect name : N-benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamideN-benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamide Synonyms: CAS NO: 1350920-22-7Molecular Formula: C22H25F3N2OMolecular Weight: 390.2Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18534654

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BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells. For Class I PI3K family, NVP-BEZ235 biochemical IC50 are 4nM against p110¦Á,75nM against p110¦Â,7nM against p110¦Ò,5nM against p110¦Ã. Quantification of S473-Akt and T308P-Akt levels by ELISA revealed that 50% reduction occurred at a compound concentration of 8.0 nmol/L and 30 nmol/L.

prudect name : BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway…

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Biological Activity of TAE684: TAE684 is a highly potent and selective smallmolecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM. NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.

prudect name : Biological Activity of TAE684: TAE684 is a highly potent and selective smallmolecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC50 values…

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Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-¦Á-induced necroptosis with EC50 of 490 nM.

prudect name : Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-¦Á-induced necroptosis with EC50 of 490 nM.Necrostatin-1 Synonyms: CAS NO: 4311-88-0Molecular Formula: C13H13N3OSMolecular Weight: 259.33Purity: 98% minSolubility: in DMSOStorage:…

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NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a Ki of 500 nM. IC50 value: 500 nM (Ki)

prudect name : NQDI-1 inhibits apoptosis signal-regulating kinase 1 (ASK1) with a Ki of 500 nM. IC50 value: 500 nM (Ki)NQDI-1;NQDI1 Synonyms: CAS NO: 175026-96-7Molecular Formula: C19H13NO4Molecular Weight: 319.31Purity: 98%…

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Neratinib is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.[1] Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.

prudect name : Neratinib is an orally available, irreversible tyrosine kinase inhibitor with IC50 of 59 nM and 92 nM for HER2 and EGFR, respectively.[1] Neratinib binds to the HER-2…

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LDE225 (NVP-LDE225) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. It has been shown to potentially inhibit Hh-and Smo-dependent proliferation in vivo. It also induced the regression of preformed basaloid lesions with an IC50 of <150 nmol/l and almost complete regression at 1.5 ¦Ìmol/l. Topical application of a 1% LDE225 (NVP-LDE225) solution to depilated skin of C57/BL6 mice completely inhibited hair growth during anagen phase as well as the expression of the Hh-pathway target genes (Gli1, Gli2, Sox9, and N-Myc) and partial inhibition was obtained when applying a 0.3% solution.

prudect name : LDE225 (NVP-LDE225) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. It has been shown to potentially inhibit Hh-and Smo-dependent proliferation…

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