MPC-3100 has been completed in phase I clinical trials for the treatment of refractory or relapsed cancer.

 June 21, 2017

prudect name : MPC-3100 has been completed in phase I clinical trials for the treatment of refractory or relapsed cancer.MPC-3100 Synonyms: CAS NO: 958025-66-6Molecular Formula: C22H25BrN6O4SMolecular Weight: 549.44Purity: 98% minSolubility:…

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mitomycine C is a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations.

prudect name : mitomycine C is a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and…

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MK-5108 inhibits Aurora-A activity in an ATP-competitive manner. MK-5108 shows robust selectivity against the other family kinases Aurora-B (220-fold) and Aurora-C (190-fold) in the biochemical assay. MK-5108 also reveals high selectivity for Aurora-A over other protein kinases. MK-5108 inhibits only one kinase (TrkA) with <100-fold selectivity. MK-5108 may be more Aurora-A selective than MLN8054. Consistent with the induction of pHH3-positive cells, MK-5108 induces accumulation of cells in the G2-M phase. MK-5108 inhibits the proliferation of tumor cells including HCC1143, AU565, MCF-7, HCC1806 and CAL85-1 with an IC50 of 0.42 ¦ÌM, 0.45 ¦ÌM, 0.52 ¦ÌM, 0.56¦ÌM and 0.74 ¦ÌM, respectively.

prudect name : MK-5108 inhibits Aurora-A activity in an ATP-competitive manner. MK-5108 shows robust selectivity against the other family kinases Aurora-B (220-fold) and Aurora-C (190-fold) in the biochemical assay. MK-5108…

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IC50 Value: MLN120B (20 umol/L) induced up to 35% and 75% inhibition, assessed by MTT assay and [3H]thymidine uptakein multiple myeloma cell lines, respectively. NF-¦ÊB pathway blockers, such as MLN120B, are currently being explored for treatment of inflammatory diseases such as COPD and asthma[3]. in vitro: MLN120B inhibits both baseline and tumor necrosis factor-¦Á-induced nuclear factor-¦ÊB activation, associated with down-regulation of I¦ÊB¦Á and p65 nuclear factor-¦ÊB phosphorylation. MLN120B triggers 25% to 90% growth inhibition in a dose-dependent fashion in multiple myeloma cell lines and significantly augments tumor necrosis factor-¦Á-induced cytotoxicity in MM.1S cells. MLN120B augments growth inhibition triggered by doxorubicin and melphalan in both RPMI 8226 and IL-6-dependent INA6 cell lines. Neither IL-6 nor IGF-1 overcomes the growth-inhibitory effect of MLN120B. MLN120B inhibits constitutive IL-6 secretion by BMSCs by 70% to 80% without affecting viability. Importantly, MLN120B almost completely blocks stimulation of MM.1S, U266, and INA6 cell growth, as well as IL-6 secretion from BMSCs, induced by multiple myeloma cell adherence to BMSCs.MLN120B mediates anti-human multiple myeloma cell activity in vivo using a novel SCID-hu model, in which multiple myeloma cells grow in vivoin the context of the human bone marrow microenvironment. Eight SCID mice were implanted with human fetal bone chips (SCID-hu), into which human IL-6-dependent INA6 cells were directly injected. These mice were treated orally with either MLN120B (50 mg/kg) or vehicle control twice daily for 3 weeks[1]. Oral administration of ML120B inhibited paw swelling in a dose-dependent manner (median effective dosage 12 mg/kg twice daily) and offered significant protection against arthritis-induced weight loss as well as cartilage and bone erosion

prudect name : IC50 Value: MLN120B (20 umol/L) induced up to 35% and 75% inhibition, assessed by MTT assay and [3H]thymidine uptakein multiple myeloma cell lines, respectively. NF-¦ÊB pathway blockers,…

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Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.Orexins/hypocretins are key neuropeptides responsible for regulating central arousal and reward circuits. Two receptors respond to orexin signaling, orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R) with partially overlapping nervous system distributions. Genetic studies suggest orexin receptor antagonists could be therapeutic for insomnia and other disorders with disruptions of sleep and wake. Suvorexant (MK-4305) was found.

prudect name : Suvorexant (MK-4305) is a potent, selective, and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.Orexins/hypocretins are key neuropeptides…

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prudect name : MestranolSynonyms: CAS NO: 72-33-3Molecular Formula: C21H26O2 Molecular Weight: 310.44Purity: 98% minSolubility: Storage:

prudect name : Mestranol Synonyms: CAS NO: 72-33-3Molecular Formula: C21H26O2 Molecular Weight: 310.44Purity: 98% minSolubility: Storage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18534076

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prudect name : Methyl 2-bromomethyl-3-nitrobenzoateSynonyms: CAS NO: 98475-07-1Molecular Formula: C9H8BrNO4Molecular Weight: 274.07Purity: 98%Solubility: Storage: −20°C

prudect name : Methyl 2-bromomethyl-3-nitrobenzoate Synonyms: CAS NO: 98475-07-1Molecular Formula: C9H8BrNO4Molecular Weight: 274.07Purity: 98%Solubility: Storage: −20°C 2 years web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18533904

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prudect name : Methyl cyclopentylphenylglycolateSynonyms: CAS NO: 19833-96-6Molecular Formula: C14H18O3Molecular Weight: 234.29Purity: 98% minSolubility: Storage:

prudect name : Methyl cyclopentylphenylglycolate Synonyms: CAS NO: 19833-96-6Molecular Formula: C14H18O3Molecular Weight: 234.29Purity: 98% minSolubility: Storage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18533899

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prudect name : Melanotan IISynonyms: CAS NO: 121062-08-6Molecular Formula: C50H69N15O9Molecular Weight: 1024.18Purity: 98% minSolubility: In

prudect name : Melanotan II Synonyms: CAS NO: 121062-08-6Molecular Formula: C50H69N15O9Molecular Weight: 1024.18Purity: 98% minSolubility: In DMSOStorage: -20¡æ web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18533776

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MCC950(CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.

prudect name : MCC950(CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.MCC950 Synonyms: CAS NO: 210826-40-7Molecular Formula: C20H24N2O5SMolecular Weight: 404.48Purity: 98% minSolubility: DMSOStorage:…

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