VD/VDR-vd-vdr.com

BIBF-1120 intermediates

June 21, 2017

prudect name : BIBF-1120 intermediatesMethyl 2-oxoindole-6-carboxylate Synonyms: CAS NO: 14192-26-8Molecular Formula: C10H9NO3Molecular Weight: 191.18Purity: 98% minSolubility: Storage: -20oC web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18525052

📌

0💬 read more

Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein(s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors.

prudect name : Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine…

📌

0💬 read more

Mizoribine applied to the same kind of immunosuppressive therapy after kidney transplantation.

prudect name : Mizoribine applied to the same kind of immunosuppressive therapy after kidney transplantation.Mizoribine Synonyms: CAS NO: 50924-49-7Molecular Formula: C9H13N3O6Molecular Weight: 259.22Purity: ≥99%Solubility: In DMSOStorage: −20°C 2 years web…

📌

0💬 read more

MSDC-0160 is a prototype mTOT-modulating insulin sensitizer [1]. MSDC-0160 is a thiazolidinedione insulin sensitizer without the peroxisome proliferator¨Cactivated receptor-¦Ã (PPAR-¦Ã)-dependent side effects. Co-incubation of islets with MSDC-0160 and IGF-1 reduces the resistance of insulin-signaling pathway and preserves insulin content. MSDC-0160 at 50¦ÌM alone also prevents the loss of insulin content significantly. Besides that, treatment of MSDC-0160 increases the phosphorylation of AMPK and reduces mTOR phosphorylation. Moreover, MSDC-0160 is also found to display pro-survival effects in human islets via reducing the level of cleaved caspase-3 and increasing the expression of apoptosis-related genes such as bcl2. In addition, MSDC-0160 exerts prevention of nuclear translocation with ¦Â-catenin localized on the cell membrane or cytoplasm in human ¦Â-cells

prudect name : MSDC-0160 is a prototype mTOT-modulating insulin sensitizer [1]. MSDC-0160 is a thiazolidinedione insulin sensitizer without the peroxisome proliferator¨Cactivated receptor-¦Ã (PPAR-¦Ã)-dependent side effects. Co-incubation of islets with MSDC-0160…

📌

0💬 read more

Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride

prudect name : Chemical Name: Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochlorideML 7 hydrochloride Synonyms: CAS NO: 110448-33-4Molecular Formula: C15H17IN2O2S.HClMolecular Weight: 452.74Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18525034

📌

0💬 read more

Maropitant (trade name Cerenia in the US and other countries), used as maropitant citrate (USAN), is a neurokinin (NK1) receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by the FDA in 2007 for use in dogs, and more recently has also been approved for use in cats.

prudect name : Maropitant (trade name Cerenia in the US and other countries), used as maropitant citrate (USAN), is a neurokinin (NK1) receptor antagonist, which was developed by Zoetis specifically…

📌

0💬 read more

Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over all proteases tested (IC50 > 67 ¦ÌM).

prudect name : Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over all proteases tested (IC50 > 67 ¦ÌM).MK-3102;Omarigliptin Synonyms: CAS NO:…

📌

0💬 read more

Roscovitine (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 µM, respectively. Roscovitine (TAK 165) also inhibits p33cdk2 and p33cdk5.Roscovitine (TAK 165) displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Roscovitine (TAK 165) exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo.

prudect name : Roscovitine (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 µM, respectively. Roscovitine (TAK 165) also inhibits p33cdk2 and p33cdk5.Roscovitine…

📌

0💬 read more

MK-2048 is a second generation integrase inhibitor, intended to be used against HIV infection.

prudect name : MK-2048 is a second generation integrase inhibitor, intended to be used against HIV infection.MK-2048 Synonyms: CAS NO: 870005-19-9Molecular Formula: C21H21ClFN5O4 Molecular Weight: 461.9 Purity: 98% minSolubility: In…

📌

0💬 read more

Chemical Name: N¡¯-[(3Z)-1-Hexyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide

prudect name : Chemical Name: N¡¯-[(3Z)-1-Hexyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazideMDA 19 Synonyms: CAS NO: 1048973-47-2Molecular Formula: C21H23N3O2Molecular Weight: 349.43Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524992

📌

0💬 read more