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Chemical Name: 3,5-Di-tert-butyl-4-hydroxybenzylidenemalononitrile

June 21, 2017

prudect name : Chemical Name: 3,5-Di-tert-butyl-4-hydroxybenzylidenemalononitrileMalonoben Synonyms: CAS NO: 10537-47-0Molecular Formula: C18H22N2OMolecular Weight: 282.38Purity: 98% minSolubility: In DMSOStorage: −20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524989

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Linagliptin shows a potent inhibition effect against DPP-4 in vitro and a low affinity for hERG channel and M1 receptor (IC50 295 nM). Linagliptin acts as a competitive inhibitor with a Ki of 1 nM, and also shows 10,000-fold more selectivity for DPP-4 than DPP-8, DPP-9, amino-peptidases N and P, prolyloligopeptidase, trypsin, plasmin, and thrombin, and 90-fold more selectivity than fibroblast activation protein in vitro.

prudect name : Linagliptin shows a potent inhibition effect against DPP-4 in vitro and a low affinity for hERG channel and M1 receptor (IC50 295 nM). Linagliptin acts as a…

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LH846 is a selective inhibitor of CK1¦Ä (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1¦Ä, ¦Å and ¦Á); displays no inhibitory activity at CK2.

prudect name : LH846 is a selective inhibitor of CK1¦Ä (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1¦Ä, ¦Å and ¦Á); displays no inhibitory activity at…

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LY315920(Varespladib) is a selective inhibitor of human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, Varespladib inhibited sPLA2 activity with an IC50 of 9.6 ¡À1 nM or 7.3 ¡Á10-6 mole fraction, which approached the stiochiometric limit of this assay.

prudect name : LY315920(Varespladib) is a selective inhibitor of human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, Varespladib inhibited sPLA2 activity with an IC50 of…

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Selective inhibitor of TGF-¦Â type-I receptor (TGF-¦Â RI, TGFR-I, T¦ÂR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-¦Â RI, TGF-¦Â RII and MLK-7K respectively). Inhibits TGF-¦Â-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.

prudect name : Selective inhibitor of TGF-¦Â type-I receptor (TGF-¦Â RI, TGFR-I, T¦ÂR-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR-¦Â RI, TGF-¦Â RII and MLK-7K respectively)….

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LY3009120 is a small molecule that has been shown in vitro to be a pan-RAF inhibitor of all isoforms, blocking proliferation in both BRAF and RAS mutant cells.

prudect name : LY3009120 is a small molecule that has been shown in vitro to be a pan-RAF inhibitor of all isoforms, blocking proliferation in both BRAF and RAS mutant…

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2-Butyl-4-chloro-1-[2¡¯-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acid

prudect name : 2-Butyl-4-chloro-1-[2¡¯-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acidLOSARTAN CARBOXYLIC ACID Synonyms: CAS NO: 124750-92-1Molecular Formula: C22H21ClN6O2Molecular Weight: 436.89Purity: 98% minSolubility: DMSOStorage: -20¡æ web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524894

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LY411575 is a selective, cell permeable, small molecule gamma secretase inhibitor with an IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. LY411575 has been exhibited to promote goblet cell differentiation in mice intestine. Concurrently, LY411575 prevents the proliferation of the cell proliferation. LY411575 has also been observed to promote neural differentiation of mouse embryonic stem (ES) cells3. The gamma-secretase inhibitor LY411575 was injected to C57BL/6 and TgCRND8 APP transgenic mice for 15 days. Although most tissues were unaffected, doses of LY411575 which prevented the production of A¦Â had significant effects on lymphocyte development and on the intestine. LY411575 decreased overall thymic cellularity and impaired intrathymic differentiation at the CD4-CD8-CD44+CD25+ precursor stage. No effects on peripheral T cell populations were observed following LY411575 treatment, but evidence for the altered maturation of peripheral B cells was observed. In the intestine, LY411575 treatment increased goblet cell number and drastically altered tissue morphology. These effects of LY411575 were not noted in mice that were administered LY-D, a diastereoisomer of LY411575, which is a very weak ¦Ã-secretase inhibitor.

prudect name : LY411575 is a selective, cell permeable, small molecule gamma secretase inhibitor with an IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. LY411575 has been exhibited…

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LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 ¦ÌM (A2780) and 0.32 ¦ÌM (A2780 CisR).

prudect name : LMK235 is a HDAC inhibitor, previously shown to be a novel and specific inhibitor of human HDAC4 and 5, with IC50 values of 0.49 ¦ÌM (A2780) and…

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prudect name : LovastatinSynonyms: CAS NO: 75330-75-5Molecular Formula: C24H36O5Molecular Weight: 404.54Purity: 98% minSolubility: Storage: -20°C

prudect name : Lovastatin Synonyms: CAS NO: 75330-75-5Molecular Formula: C24H36O5Molecular Weight: 404.54Purity: 98% minSolubility: Storage: -20°C web site: www.medchemexpress.com References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18524878/

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