prudect name : LuprostiolSynonyms: CAS NO: 67110-79-6Molecular Formula: C21H29ClO6SMolecular Weight: 444.973Purity: 99% minSolubility: Storage: −20°C

 June 21, 2017

prudect name : Luprostiol Synonyms: CAS NO: 67110-79-6Molecular Formula: C21H29ClO6SMolecular Weight: 444.973Purity: 99% minSolubility: Storage: −20°C KD-025 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18522734

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Lubiprostone is a chloride channel activator limitations, the treatment of adult chronic idiopathic constipation.

prudect name : Lubiprostone is a chloride channel activator limitations, the treatment of adult chronic idiopathic constipation.Lubiprostone Synonyms: CAS NO: 136790-76-6 333963-40-9Molecular Formula: C20H32F2O5Molecular Weight: 390.46Purity: 99%Solubility: In DMSOStorage: −20°C…

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prudect name : LacosamideSynonyms: CAS NO: 175481-36-4Molecular Formula: C13H18N2O3Molecular Weight: 250.29Purity: 99%Solubility: Storage: −20°C 2

prudect name : Lacosamide Synonyms: CAS NO: 175481-36-4Molecular Formula: C13H18N2O3Molecular Weight: 250.29Purity: 99%Solubility: Storage: −20°C 2 years AZD-2281 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18522490

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prudect name : LinezolidSynonyms: CAS NO: 165800-03-3Molecular Formula: C16H20FN3O4Molecular Weight: 337.35Purity: 99% minSolubility: Storage: −20°C

prudect name : Linezolid Synonyms: CAS NO: 165800-03-3Molecular Formula: C16H20FN3O4Molecular Weight: 337.35Purity: 99% minSolubility: Storage: −20°C MK 8628 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18522411

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prudect name : LinaclotideSynonyms: CAS NO: 851199-59-2Molecular Formula: C59H79N15O21S6Molecular Weight: 1526.74Purity: 98% minSolubility: Storage: -20°C

prudect name : Linaclotide Synonyms: CAS NO: 851199-59-2Molecular Formula: C59H79N15O21S6Molecular Weight: 1526.74Purity: 98% minSolubility: Storage: -20°C E-7438 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18522407

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prudect name : LiranaftateSynonyms: CAS NO: 88678-31-3Molecular Formula: C18H20N2O2SMolecular Weight: 328.43Purity: 99%Solubility: Storage: −20°C 2

prudect name : Liranaftate Synonyms: CAS NO: 88678-31-3Molecular Formula: C18H20N2O2SMolecular Weight: 328.43Purity: 99%Solubility: Storage: −20°C 2 years RVX 208 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18522263

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KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. A-T fibroblasts were not radiosensitized by KU-60019, strongly suggesting that the ATM kinase is specifically targeted. Furthermore, KU-60019 reduced basal S473 AKT phosphorylation, suggesting that the ATM kinase might regulate a protein phosphatase acting on AKT. In line with this finding, the effect of KU-60019 on AKT phosphorylation was countered by low levels of okadaic acid, a phosphatase inhibitor, and A-T cells were impaired in S473 AKT phosphorylation in response to radiation and insulin and unresponsive to KU-60019.

prudect name : KU-60019 is 10-fold more effective than KU-55933 at blocking radiation-induced phosphorylation of key ATM targets in human glioma cells. As expected, KU-60019 is a highly effective radiosensitizer…

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Ku-0063794 is a specific inhibitor of mTOR, which inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks at 1000-fold higher concentrations. Ku-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK. Ku-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. Ku-0063794 is a prototype of mTOR inhibitor AZD8055 currently in Phase I/II trial in Advance Solid Tumors, Lymphoma and Endometrial Carcinoma.

prudect name : Ku-0063794 is a specific inhibitor of mTOR, which inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of…

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Chemical Name: 2-(4-Ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide trihydrochloride

prudect name : Chemical Name: 2-(4-Ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide trihydrochlorideKU 0060648 trihydrochloride Synonyms: CAS NO: 881375-00-4Molecular Formula: C33H34N4O4S.3HClMolecular Weight: 692.10Purity: 98% minSolubility: In DMSOStorage: -20°C PKC 412 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18521965

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KW-2478 inhibits the binding of bRD to Hsp90¦Á with IC50 of 3.8 nM. KW-2478 degradates the Hsp90 client proteins, including FGFR3 and IGF-1R¦Âand c-Raf-1. KW-2478 reduces the level of phosphorylated Erk1/2. KW-2478 induces apoptosis by cleavage of PARP, a substrate of caspase-3 In U266 cells,. KW-2478 has Time dependency of antiproliferative activity, consecutive drug exposure for at least 12 hours is necessary to to exert potent antitumor activity. KW-2478 downregulates the translocation products of IgH locus. KW-2478 inhibits the transcription of c-Maf and cyclin D1 genes by mainly suppressing the function of Cdk9.

prudect name : KW-2478 inhibits the binding of bRD to Hsp90¦Á with IC50 of 3.8 nM. KW-2478 degradates the Hsp90 client proteins, including FGFR3 and IGF-1R¦Âand c-Raf-1. KW-2478 reduces the…

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