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MK-677; 2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4¡¯-piperidin]-1¡¯-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate

June 21, 2017

prudect name : MK-677; 2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4¡¯-piperidin]-1¡¯-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonateIbutamoren mesylate MK-677 Synonyms: CAS NO: 624.77Molecular Formula: C27H36N4O5S.CH4O3SMolecular Weight: 624.77Purity: 98% minSolubility: In DMSOStorage: -20°C SU 5416 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519244

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Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell).

prudect name : Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress(IC50=3 uM,…

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HMN-214(a prodrug of HMN-176) is a potent PLK1 inhibitor (an average cell IC50 of 118 nM). HMN-214 is an oral stilbene derivative. HMN-176 interferes with PLK1, but does not appear to directly inhibit PLK1. Instead, it alters its spatial distribution, resulting in cell cycle arrest at the G2¨CM phase, with destruction of the spindle polar bodies followed by DNA fragmentation. Drug-resistant cell lines showed low crossresistance to HMN-176. In human tumor xenografts, there was a broad spectrum of antitumor activity. The antitumor activity of HMN-214 was equal or superior to that of clinically available agents, including cisplatin, doxorubicin, vincristine, and tegafur-uracil .

prudect name : HMN-214(a prodrug of HMN-176) is a potent PLK1 inhibitor (an average cell IC50 of 118 nM). HMN-214 is an oral stilbene derivative. HMN-176 interferes with PLK1, but…

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Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride

prudect name : Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochlorideHA 1100 hydrochloride Synonyms: CAS NO: 105628-72-6Molecular Formula: C14H17N3O3S.HClMolecular Weight: 343.83Purity: 98% minSolubility: In DMSOStorage: −20°C MK 0974 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519069

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prudect name : HQL 79Synonyms: 4-(Diphenylmethoxy)-1-[3-(2H-tetrazol-5-yl)propyl]piperidineCAS NO: 162641-16-9Molecular Formula: C22H27N5OMolecular Weight: 377.48Purity: 98% minSolubility: In

prudect name : HQL 79 Synonyms: 4-(Diphenylmethoxy)-1-[3-(2H-tetrazol-5-yl)propyl]piperidineCAS NO: 162641-16-9Molecular Formula: C22H27N5OMolecular Weight: 377.48Purity: 98% minSolubility: In DMSOStorage: −20°C FG 4592 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18519043

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Biological Activity Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 ¦ÌM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

prudect name : Biological Activity Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC50 = 0.8 ¦ÌM). Stabilizes p53…

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Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. H-89 is a potent, cell permeable inhibitor of PKA that demonstrates an IC50 value of 0.14 µM and a Ki value of 48 nM in standard kinase assays.While widely used to disrupt PKA signaling, the inhibitory activity of H-89 is non-selective. H-89 also inhibits S6K1, MSK1, ROCK-II, PKB¦Á, and MAPKAP-K1b with IC50 values of 0.08, 0.12, 0.27, 2.6, and 2.8 µM, respectively.

prudect name : Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. H-89…

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HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM)

prudect name : HG-10-102-01 is a potent and selective inhibitor of wild-type LRRK2(IC50=23.3 nM) and the G2019S mutant(IC50=3.2 nM)HG-10-102-01 Synonyms: CAS NO: 1351758-81-0Molecular Formula: C17H20ClN5O3Molecular Weight: 377.83Purity: 98% minSolubility: In…

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Hydroxyurea tablets can be reduced to prevent deoxynucleotidyl nucleotide, purine and pyrimidine bases interfere with the biosynthesis, DNA synthesis selectively impede.

prudect name : Hydroxyurea tablets can be reduced to prevent deoxynucleotidyl nucleotide, purine and pyrimidine bases interfere with the biosynthesis, DNA synthesis selectively impede.Hydroxyurea Synonyms: CAS NO: 127-07-1Molecular Formula: CH4N2O2Molecular…

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prudect name : HydroxycamptothecinSynonyms: CAS NO: 19685-09-7Molecular Formula: C20H16N2O5Molecular Weight: 364.357Purity: ≥99%Solubility: Storage: −20°C

prudect name : Hydroxycamptothecin Synonyms: CAS NO: 19685-09-7Molecular Formula: C20H16N2O5Molecular Weight: 364.357Purity: ≥99%Solubility: Storage: −20°C 2 years MLN 4924 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18518933

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