GLPG0634(filgotinib) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively

June 21, 2017

prudect name : GLPG0634(filgotinib) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectivelyGLPG0634(filgotinib) Synonyms: CAS…

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GW-6604;2-Phenyl-4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridine

prudect name : GW-6604;2-Phenyl-4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridineGW-6604 Synonyms: CAS NO: 452342-37-9Molecular Formula: C19H14N4Molecular Weight: 298.34126Purity: 98% minSolubility: in DMSOStorage: -20oC RG-7388 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18517923

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GSK525762 is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor GSK525762 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth.

prudect name : GSK525762 is a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor GSK525762 binds…

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Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid

prudect name : Chemical Name: 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acidGW 9508 Synonyms: CAS NO: 885101-89-3Molecular Formula: C22H21NO3Molecular Weight: 347.41Purity: 98% minSolubility: In DMSOStorage: -20°C TAK 242 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18517654

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4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

prudect name : 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONEGSK-3InhibitorI,TDZD-8;NP 01139 Synonyms: GSK-3InhibitorI,TDZD-8;NP 01139CAS NO: 327036-89-5Molecular Formula: C10H10N2O2SMolecular Weight: 222.26Purity: 98% minSolubility: In DMSOStorage: −20°C MDV 3100 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/1851724

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G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice.

prudect name : G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50…

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GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22ยกร€0.1 uM (Wild type Abl).

prudect name : GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22ยกร€0.1 uM (Wild type Abl).GNF-5;GNF…

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GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

prudect name : GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.GS-7340(Tenofovir alafenamide) Synonyms: CAS NO: 379270-37-8Molecular…

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GSK-503 is a potent EZH2 inhibitor with potential anticancer activity.

prudect name : GSK-503 is a potent EZH2 inhibitor with potential anticancer activity.GSK-503;GSK503 Synonyms: CAS NO: 1346572-63-1Molecular Formula: C31H38N6O2Molecular Weight: 526.67Purity: 98% minSolubility: In DMSOStorage: -20°C ABR 215062 References PubMed…

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SC-203877;5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine

prudect name : SC-203877;5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamineGW2580 Synonyms: CAS NO: 870483-87-7Molecular Formula: C20H22N4O3Molecular Weight: 366.41368Purity: 98% minSolubility: In DMSOStorage: −20°C JTC801 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18517032

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