Dacinostat (NVP-LAQ824, LAQ824) is a highly potent HDAC inhibitor with IC50 of 32 nM,LAQ824 induces chromatin changes at the level of the IL-10 gene promoter that lead to enhanced recruitment of the transcriptional repressors HDAC11 and PU.1 and inhibits IL-10 production in BALB/c murine macrophages [

 June 21, 2017

prudect name : Dacinostat (NVP-LAQ824, LAQ824) is a highly potent HDAC inhibitor with IC50 of 32 nM,LAQ824 induces chromatin changes at the level of the IL-10 gene promoter that lead…

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prudect name : Diphenylmethyl 7beta-Tert-Butoxycarbonylamino-3-Chloromethyl-3-Cephem-4-CarboxylateSynonyms: CAS NO: 112028-91-8Molecular Formula: C26H27ClN2O5SMolecular Weight: 515.02098Purity: 98% minSolubility: Storage:

prudect name : Diphenylmethyl 7beta-Tert-Butoxycarbonylamino-3-Chloromethyl-3-Cephem-4-Carboxylate Synonyms: CAS NO: 112028-91-8Molecular Formula: C26H27ClN2O5SMolecular Weight: 515.02098Purity: 98% minSolubility: Storage: −20°C BQ 788 sodium salt References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511549

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trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid

prudect name : trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acidDGAT-3 Synonyms: CAS NO: 701232-20-4Molecular Formula: C22H26N4O3Molecular Weight: 394.47Purity: 98% minSolubility: In DMSOStorage: -20°C LY-2606368 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511518

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Dronedarone hydrochloride for the treatment of arrhythmia.

prudect name : Dronedarone hydrochloride for the treatment of arrhythmia.Dronedarone hydrochloride Synonyms: CAS NO: 141625-93-6Molecular Formula: C31H44N2O5S.HClMolecular Weight: 593.22Purity: 99%Solubility: Storage: −20°C 2 years EPZ6438 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511498

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prudect name : DacarbazineSynonyms: CAS NO: 4342-03-4Molecular Formula: C6H10N6OMolecular Weight: 182.18Purity: 99%Solubility: Storage: −20°C

prudect name : Dacarbazine Synonyms: CAS NO: 4342-03-4Molecular Formula: C6H10N6OMolecular Weight: 182.18Purity: 99%Solubility: Storage: −20°C 2 years IPI 549 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511463

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Tetrandrine (Fanchinine; Hanfangchin A) is a calcium channel blocker with an IC50 of 38.23¡À 25.77 ¦ÌM. Tetrandrine (Fanchinine; Hanfangchin A) has anti-inflammatory, immunologic and antiallergenic effects. Tetrandrine (Fanchinine; Hanfangchin A) inhibits the degranulation of mast cells. Tetrandrinehas a “Quinidine like” anti-arrhythmic effect. Tetrandrine (Fanchinine; Hanfangchin A) has been isolated from Stephania tetandra and other Chinese and Japanese Herbs. Tetrandrine (Fanchinine; Hanfangchin A) increased populations of both apoptotic sub-G1 and G1 phase. Tetrandrine-induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of cyclin D1 and activation of caspase-3. Tetrandrine (Fanchinine; Hanfangchin A) also affected the expression patterns of cytoskeletons including distribution of F-actin and expression level of microtubule.

prudect name : Tetrandrine (Fanchinine; Hanfangchin A) is a calcium channel blocker with an IC50 of 38.23¡À 25.77 ¦ÌM. Tetrandrine (Fanchinine; Hanfangchin A) has anti-inflammatory, immunologic and antiallergenic effects. Tetrandrine…

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prudect name : D-CloprostenolSynonyms: (+)-15(S)-CloprostenolCAS NO: 54276-22-1Molecular Formula: C22H29ClO6Molecular Weight: 424.9Purity: 98% minSolubility: Storage: -20¡æ

prudect name : D-Cloprostenol Synonyms: (+)-15(S)-CloprostenolCAS NO: 54276-22-1Molecular Formula: C22H29ClO6Molecular Weight: 424.9Purity: 98% minSolubility: Storage: -20¡æ ABT199 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511409

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(3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-2,5,6,10,13-pentaazatetradecanedioic acid 1,14-dimethyl ester

prudect name : (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-2,5,6,10,13-pentaazatetradecanedioic acid 1,14-dimethyl esterDes(benzylpyridyl) Atazanavi Synonyms: CAS NO: 1192224-24-0Molecular Formula: C26H43N5O7Molecular Weight: 537.65Purity: 98% minSolubility: in DMSOStorage: -20oC LMI-070 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511348

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JAK3 Inhibitor

prudect name : JAK3 InhibitorDecernotinib (VX-509) Synonyms: CAS NO: 944842-54-0Molecular Formula: Molecular Weight: 392.38Purity: 98% minSolubility: in DMSOStorage: -20oC RG 7388 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511335

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Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.

prudect name : Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit…

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