Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.

 June 21, 2017

prudect name : Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit…

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Dalbavancin is a novel second-generation lipoglycopeptide antibiotic. It belongs to the same class as vancomycin, the most widely used and one of the few treatments available to patients infected with methicillin-resistant Staphylococcus aureus (MRSA). Dalbavancin is a semisynthetic lipoglycopeptide that was designed to improve upon the natural glycopeptides currently available, vancomycin and teicoplanin. It possesses in vitro activity against a variety of Gram-positive pathogens including MRSA and methicillin-resistant Staphylococcus epidermidis (MRSE). Dalbavancin was approved in May 2014 for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by certain susceptible bacteria such as Staphylococcus aureus including methicillin-susceptible and methicillin-resistant strains of Streptococcus pyogenes, in intravenous dosage form.

prudect name : Dalbavancin is a novel second-generation lipoglycopeptide antibiotic. It belongs to the same class as vancomycin, the most widely used and one of the few treatments available to…

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Decitabine is an available nucleoside-based DNA methyltransferase (DNMT) inhibitor with IC50 of 490, 400 and 100 nM for A549, LoVo and LoVo-DX cell lines.Decitabine was demonstrated to have a wide range of anti-metabolic activities when tested against cultured cancer cells and to be an effective chemotherapeutic agent for acute myelogenous leukemia. However, because of 5-azacytidine

prudect name : Decitabine is an available nucleoside-based DNA methyltransferase (DNMT) inhibitor with IC50 of 490, 400 and 100 nM for A549, LoVo and LoVo-DX cell lines.Decitabine was demonstrated to…

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prudect name : DepofeminSynonyms: CAS NO: 313-06-4Molecular Formula: C26H36O3Molecular Weight: 396.57Purity: 98% minSolubility: Storage: −20°C

prudect name : Depofemin Synonyms: CAS NO: 313-06-4Molecular Formula: C26H36O3Molecular Weight: 396.57Purity: 98% minSolubility: Storage: −20°C MDV-3100 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511238

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Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc.

prudect name : Danusertib (PHA-739358) is an Aurora kinase inhibitor for Aurora A/B/C with IC50 of 13 nM/79 nM/61 nM in cell-free assays, modestly potent to Abl, TrkA, c-RET and…

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Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus (IC50=0.5¦ÌM). On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) has the highest preference for two adjacent G/C base pairs flanked on the 5¡¯ side by an A/T base pair. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) effectively binds to every 3 base pairs and induces a local unwinding angle of 11o, but negligible distortion of helical conformation. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is most commonly used to treat specific types of leukaemia (acute myeloid leukemia and acute lymphocytic leukemia). Cerubidine (Daunorubicin HCl, Rubidomycin HCl) was initially isolated from Streptomyces peucetius.

prudect name : Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus (IC50=0.5¦ÌM). On binding to DNA, daunomycin…

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Adriamycin (Doxorubicin) is a topoisomerase II inhibitor with IC50 of 1 and 2 ¦ÌM for the inhibition of MCF-7 and MDA-MB231, respectively. Adriamycin (Doxorubicin) is an anthracycline antibiotic and is used in cancer chemotherapy. Adriamycin (Doxorubicin) inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

prudect name : Adriamycin (Doxorubicin) is a topoisomerase II inhibitor with IC50 of 1 and 2 ¦ÌM for the inhibition of MCF-7 and MDA-MB231, respectively. Adriamycin (Doxorubicin) is an anthracycline…

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Bimatoprost & Latanoprost intermediates

prudect name : Bimatoprost & Latanoprost intermediatesDimethyl (2-oxo-4-phenylbutyl)phosphonate Synonyms: BMPCAS NO: 41162-19-0Molecular Formula: C12H17O4PMolecular Weight: 256.23Purity: 98% minSolubility: Storage: -20¡æ CGP41251 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511168

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Potent non-nucleoside reverse transcriptase inhibitor (NNRTI); an antiretroviral compound designed to prevent or interrupt HIV replication in human cells; safe and tolerable as potential vaginal microbicide.

prudect name : Potent non-nucleoside reverse transcriptase inhibitor (NNRTI); an antiretroviral compound designed to prevent or interrupt HIV replication in human cells; safe and tolerable as potential vaginal microbicide.Dapivirine Synonyms:…

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prudect name : Dimethyl [2-oxo-3-[3-(trifluoromethyl)phenoxy]propyl]phosphonateSynonyms: TVPCAS NO: 54094-19-8Molecular Formula: C12H14F3O5PMolecular Weight: 326.21Purity: 98% minSolubility: Storage:

prudect name : Dimethyl [2-oxo-3-[3-(trifluoromethyl)phenoxy]propyl]phosphonate Synonyms: TVPCAS NO: 54094-19-8Molecular Formula: C12H14F3O5PMolecular Weight: 326.21Purity: 98% minSolubility: Storage: -20¡æ ABR-215062 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18511141

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