Dovitinib Dilactic acid (TKI258 Dilactic acid) is a highly potent, novel multitargeted growth factor receptor kinase inhibitor with IC50 of 1, 2, 10, 8, 27, 36 nM for FLT3, c-KIT, VEGFR1/2/3, PDGFRß and CSF-1R, respectively. It shows both antitumor and antiangiogenic activities in vivo.It potently inhibits FGFR3 with an inhibitory concentration of 50% (IC50) of 5 nM in in vitro kinase assays and selectively inhibited the growth of B9 cells and human myeloma cell lines expressing wild-type (WT) or activated mutant FGFR3. Antiproliferative activity of Dovitinib Dilactic acid (TKI258 Dilactic acid) against MV4;11 was ~24-fold greater compared with RS4;11, indicating more potent inhibition against cells with constitutively activated FLT3 ITD.

June 21, 2017

prudect name : Dovitinib Dilactic acid (TKI258 Dilactic acid) is a highly potent, novel multitargeted growth factor receptor kinase inhibitor with IC50 of 1, 2, 10, 8, 27, 36 nM…

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Dasatinib (BMS-354825) is an ATP-competitive, dual SRC/ABL inhibitor. Dasatinib is a potent inhibitor of imatinib-resistant KIT activation loop mutants and induces apoptosis in mast cell and leukemic cell lines expressing these mutations. Dasatinib sensitively inhibits all members of the Src family, including c-Src, Lck, Fyn, and Yes (IC50 < 1.1nmol/L). At higher concentrations (3 to 28 nmol/L), dasatinib also inhibits the Src kinases Abl, c-Kit, PDGFR, and EphA2.

prudect name : Dasatinib (BMS-354825) is an ATP-competitive, dual SRC/ABL inhibitor. Dasatinib is a potent inhibitor of imatinib-resistant KIT activation loop mutants and induces apoptosis in mast cell and leukemic…

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prudect name : DienogestSynonyms: CAS NO: 65928-58-7Molecular Formula: C20H25NO2Molecular Weight: 311.42Purity: 99% minSolubility: Storage: −20°C

prudect name : Dienogest Synonyms: CAS NO: 65928-58-7Molecular Formula: C20H25NO2Molecular Weight: 311.42Purity: 99% minSolubility: Storage: −20°C PP242 References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18510965/

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D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to ¦Á¦Â-Tubulin. D-64131 is cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). D-64131 prevents growth of tumor models in mice following oral administration in vivo. D-64131 has significant potential in cancer treatment.

prudect name : D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to ¦Á¦Â-Tubulin. D-64131 is cytotoxic and inhibits tumor cell proliferation in vitro (IC50 =…

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prudect name : Deslorelin AcetateSynonyms: CAS NO: 5773-65-6Molecular Formula: C64H83N17O12Molecular Weight: 1282.47Purity: 98% minSolubility: Storage:

prudect name : Deslorelin Acetate Synonyms: CAS NO: 5773-65-6Molecular Formula: C64H83N17O12Molecular Weight: 1282.47Purity: 98% minSolubility: Storage: -20°C Torin2 References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18510932

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prudect name : Didesethylflurazepam dihydrochlorideSynonyms: CAS NO: 19603-97-5Molecular Formula: C17H15ClFN3O.2(HCl)Molecular Weight: 404.70Purity: 98% minSolubility: Storage:

prudect name : Didesethylflurazepam dihydrochloride Synonyms: CAS NO: 19603-97-5Molecular Formula: C17H15ClFN3O.2(HCl)Molecular Weight: 404.70Purity: 98% minSolubility: Storage: -20°C PGE1 References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18510890/

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duloxetine for the treatment of depression, depressive neurosis and schizophrenia depression

prudect name : duloxetine for the treatment of depression, depressive neurosis and schizophrenia depressionDuloxetine Synonyms: CAS NO: 116539-59-4Molecular Formula: C18H19NOSMolecular Weight: 297.41Purity: ≥99%Solubility: Storage: −20°C 2 years IPI-145 References PubMed…

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prudect name : Darifenacin hydrobromideSynonyms: CAS NO: 133099-07-7Molecular Formula: C28H30N2O2.HBrMolecular Weight: 507.47Purity: ≥99%Solubility: Storage: −20°C

prudect name : Darifenacin hydrobromide Synonyms: CAS NO: 133099-07-7Molecular Formula: C28H30N2O2.HBrMolecular Weight: 507.47Purity: ≥99%Solubility: Storage: −20°C 2 years GDC-0917 References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18510807

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BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors. It is being studied for various clinical indications and in many cases it offers an alternative to warfarin as the preferred orally administered blood thinner since it does not require prothrombin time monitoring while offering similar results in terms of efficacy.

prudect name : BIBR-1048 (Dabigatran) is an anticoagulant from the class of the direct thrombin inhibitors. It is being studied for various clinical indications and in many cases it offers…

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Dynasore is a cell-permeable, reversible non-competitive dynamininhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 ¦ÌM, also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase.

prudect name : Dynasore is a cell-permeable, reversible non-competitive dynamininhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 ¦ÌM, also inhibits the mitochondrial dynamin Drp1, with no effect…

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