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Department of the Swiss Sandoz clozapine (the predecessor of Novartis) in 1961 and the successful development of antipsychotic drugs and are diphenyl compounds of nitrous Zhuoyan Sheng property

June 21, 2017

prudect name : Department of the Swiss Sandoz clozapine (the predecessor of Novartis) in 1961 and the successful development of antipsychotic drugs and are diphenyl compounds of nitrous Zhuoyan Sheng…

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CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 ¦ÌM, 24 ¦ÌM and 32 ¦ÌM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.

prudect name : CK-636 is an Arp2/3 complex inhibitor with IC50 of 4 ¦ÌM, 24 ¦ÌM and 32 ¦ÌM for inhibition of actin polymerization induced by human, fission yeast and…

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2-((4R)-8-chloro-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

prudect name : 2-((4R)-8-chloro-6-(4-chlorophenyl)-1-methyl-4H-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamideCPI-268456 Synonyms: CAS NO: 1380087-86-4Molecular Formula: C20H15Cl2N3O2 Molecular Weight: 400.264 Purity: 98% minSolubility: DMSOStorage: -20¡æ AG-221 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18507059

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Clemastine fumarate is a highly efficient, low toxicity, long-term, small amount of anti-allergy

prudect name : Clemastine fumarate is a highly efficient, low toxicity, long-term, small amount of anti-allergyClemastine Fumarate Synonyms: CAS NO: 14976-57-9Molecular Formula: C25H30ClNO5Molecular Weight: 459.96Purity: ≥98%Solubility: Storage: −20°C 2 years…

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CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFR¦Â and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2

prudect name : CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFR¦Â and…

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CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer.

prudect name : CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models ….

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Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis.

prudect name : Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM)…

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Cariprazine(RGH188) is a novel antipsychotic drug candidate that exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors.

prudect name : Cariprazine(RGH188) is a novel antipsychotic drug candidate that exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin…

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Synonyms:2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanol

prudect name : Synonyms:2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanolCardiogenol C Synonyms: CAS NO: 671225-39-1Molecular Formula: C13H16N4O2Molecular Weight: 260.29Purity: 98% minSolubility: In DMSOStorage: -20 oC mGluR5 inhibitor References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1850690

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prudect name : CladribineSynonyms: CAS NO: 4291-63-8Molecular Formula: C10H12ClN5O3Molecular Weight: 285.69Purity: 98% minSolubility: In DMSOStorage:

prudect name : Cladribine Synonyms: CAS NO: 4291-63-8Molecular Formula: C10H12ClN5O3Molecular Weight: 285.69Purity: 98% minSolubility: In DMSOStorage: −20°C CPI203 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18506855

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