CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level.

 June 21, 2017

prudect name : CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional…

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prudect name : CyclopropanesulfonamideSynonyms: CAS NO: 154350-29-5Molecular Formula: C3H7NO2SMolecular Weight: 121.15Purity: 99%Solubility: Storage: −20°C

prudect name : Cyclopropanesulfonamide Synonyms: CAS NO: 154350-29-5Molecular Formula: C3H7NO2SMolecular Weight: 121.15Purity: 99%Solubility: Storage: −20°C 2 years LCL-161 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18505980

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GM6001 (galardin, ilomastat) is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4-27 nM.

prudect name : GM6001 (galardin, ilomastat) is a broad spectrum MMPs inhibitor for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26 with Ki of 0.4-27 nM.CS 610; GM…

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prudect name : cis,cis,cis-1,2,3,4-Tetrakis[(diphenylphosphino)methyl]cyclopentaneSynonyms: CAS NO: 333380-86-2Molecular Formula: C53H46P4Molecular Weight: 806.83Purity: 98% minSolubility: Storage: -20°C

prudect name : cis,cis,cis-1,2,3,4-Tetrakis[(diphenylphosphino)methyl]cyclopentane Synonyms: CAS NO: 333380-86-2Molecular Formula: C53H46P4Molecular Weight: 806.83Purity: 98% minSolubility: Storage: -20°C BMS-354825 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18505837

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Clopidogrel bisulfate is a new and efficient anti-platelet drugs

prudect name : Clopidogrel bisulfate is a new and efficient anti-platelet drugsClopidogrel bisulfate Synonyms: CAS NO: 120202-66-6Molecular Formula: C16H16ClNO2S.H2SO4Molecular Weight: 419.03Purity: 99%Solubility: Storage: −20°C 2 years Osimertinib mesylate References PubMed…

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prudect name : CordycepinSynonyms: CAS NO: 73-03-0Molecular Formula: C10H13N5O3Molecular Weight: 251.24Purity: 98% minSolubility: Storage: -20°C

prudect name : Cordycepin Synonyms: CAS NO: 73-03-0Molecular Formula: C10H13N5O3Molecular Weight: 251.24Purity: 98% minSolubility: Storage: -20°C ABT-450 References PubMed ID๏ผš:http://www.ncbi.nlm.nih.gov/pubmed/18505822

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CH5424802 is current under Phase I/II studies in patients with ALK-rearranged non-small cell lung cancer.

prudect name : CH5424802 is current under Phase I/II studies in patients with ALK-rearranged non-small cell lung cancer.CH 5424802 Synonyms: CAS NO: 1256580-46-7Molecular Formula: C30H34N4O2Molecular Weight: 482.62Purity: 98%Solubility: In DMSOStorage:…

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CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 ยฆรŒM. Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA Polymerase I (Pol I), the multi-protein complex that synthesizes rRNA, is activated widely in cancer. Thus, selective inhibitors of RNA PolI may offer a general therapeutic strategy to block cancer cell proliferation. CX-5461 selectively blocks RNA PolI transcription,PIC assembly and SL1-rDNA interaction. CX-5461 indicates potent antiproliferative activity in cancer cells and induces autophagy incancer cells. CX-5461 shows potent antitumor activity in A375 and MiaPaca xenografts.

prudect name : CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 ยฆรŒM. Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA Polymerase…

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Potent inhibitor of Aurora kinases (IC50 values are 0.015, 0.019 and 0.025 ยฆรŒM at Aurora A, Aurora C and Aurora B respectively). Displays antiproliferative activity in a range of human tumor cell lines. Orally bioavailable.

prudect name : Potent inhibitor of Aurora kinases (IC50 values are 0.015, 0.019 and 0.025 ยฆรŒM at Aurora A, Aurora C and Aurora B respectively). Displays antiproliferative activity in a…

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CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.

prudect name : CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.CID 755673 Synonyms: CAS NO: 521937-07-5Molecular…

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