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AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.

June 21, 2017

prudect name : AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may…

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Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.

prudect name : Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist…

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ABT-751 is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. In preclinical studies, ABT-751 showed antitumor activity against a broad spectrum of tumor lines and human xenograft models (colon, nasopharyngeal,lung, stomach, breast, pancreas, prostate). ABT-751 is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. ABT-751 also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect. ABT-751 is currently under clinical development for cancer treatment.

prudect name : ABT-751 is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 µM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 binds…

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AZD1152-HQPA (Barasertib) is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM. AZD1152-HQPA (Barasertib) inhibits Aurora A with a Ki of 1.37 nM. AZD1152 is converted rapidly to the active AZD1152-HQPA (Barasertib) in plasma. AZD1152-HQPA (Barasertib) has a high specificity versus a panel of 50 other kinases. Consistent with inhibition of Aurora B kinase, addition of AZD1152-HQPA (Barasertib) to tumor cells in vitro induces chromosome misalignment, prevents cell division, and consequently reduces cell viability and induces apoptosis.

prudect name : AZD1152-HQPA (Barasertib) is a highly potent and selective Aurora B inhibitor with a Ki of 0.36 nM. AZD1152-HQPA (Barasertib) inhibits Aurora A with a Ki of 1.37…

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prudect name : ArgirelineSynonyms: CAS NO: 616204-22-9Molecular Formula: C34H60N14O12SMolecular Weight: 888.99Purity: 98% minSolubility: Storage: -20°C

prudect name : Argireline Synonyms: CAS NO: 616204-22-9Molecular Formula: C34H60N14O12SMolecular Weight: 888.99Purity: 98% minSolubility: Storage: -20°C 139504-50-0 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498740/

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prudect name : Angiotensin acetateSynonyms: CAS NO: 58-49-1Molecular Formula: C49H70N14O11Molecular Weight: 1031.17Purity: 98% minSolubility: In

prudect name : Angiotensin acetate Synonyms: CAS NO: 58-49-1Molecular Formula: C49H70N14O11Molecular Weight: 1031.17Purity: 98% minSolubility: In DMSOStorage: -20°C 60940-34-3 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498717

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AZD2461 is a novel PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by Pgp

prudect name : AZD2461 is a novel PARP inhibitor, which has the potential to avoid the olaparib resistence mediated by PgpAZD2461 Synonyms: CAS NO: 1174043-16-3Molecular Formula: C22H22FN3O3Molecular Weight: 395.43Purity: 98%…

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(R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide

prudect name : (R)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamideApremilast enantiomer Synonyms: CAS NO: 608141-44-2Molecular Formula: C22H24N2O7SMolecular Weight: 460.5Purity: 98% minSolubility: In DMSOStorage: -20 oC 338967-87-6 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18498625

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Argatroban is a thrombin inhibitor, reversibly combine with the active site of thrombin.

prudect name : Argatroban is a thrombin inhibitor, reversibly combine with the active site of thrombin.Argatroban Synonyms: CAS NO: 141396-28-3Molecular Formula: C23H36N6O5S.H2OMolecular Weight: 526.65Purity: 99%Solubility: Storage: −20°C 2 years 229975-97-7…

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AS-252424 is a potent and selective PI3k ¦Ã inhibitor with IC50 of 33 and 935 nM for PI3K¦Ã and PI3K¦Á, respectively. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of Pl at the 3 position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. AS-252424 inhibits human recombinant PI3K¦Â, and ¦Ä with IC50 values of 20,000, and 20,000 nM, respectively. AS-252424 also prevents C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 of 0.23 µM. AS-252424 inhibited neutrophil recruitment 35% at a dose of 10 mg/kg in a mouse model of peritonitis

prudect name : AS-252424 is a potent and selective PI3k ¦Ã inhibitor with IC50 of 33 and 935 nM for PI3K¦Ã and PI3K¦Á, respectively. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation…

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