Chemical Name: (-)-1,1¡¯,6,6¡¯,7,7¡¯-Hexahydroxy-3,3¡¯-dim­ethyl-5,5¡¯-bis(1-methylethyl)-[2,2¡¯-binaphthalene]-8­,8¡¯-dicarboxaldehyde

 June 21, 2017

prudect name : Chemical Name: (-)-1,1¡¯,6,6¡¯,7,7¡¯-Hexahydroxy-3,3¡¯-dim­ethyl-5,5¡¯-bis(1-methylethyl)-[2,2¡¯-binaphthalene]-8­,8¡¯-dicarboxaldehydeAT 101 Synonyms: (-)-GossypolCAS NO: 90141-22-3Molecular Formula: C30H30O8Molecular Weight: 518.55Purity: 98% minSolubility: In DMSOStorage: -20°C 851983-85-2 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18497260

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AGI-6780 is a potent and selective IDH2 inhibitor. AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q. Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro. Inhibitors targeting mutant IDH2/R140Q could have potential applications as a differentiation therapy for cancer.

prudect name : AGI-6780 is a potent and selective IDH2 inhibitor. AGI-6780 inhibits the tumor-associated mutant IDH2/R140Q. Treatment with AGI-6780 induced differentiation of TF-1 erythroleukemia and primary human acute myelogenous…

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prudect name : AN-2690(Tavaborole)Synonyms: 5-Fluoro-2,1-Benzoxaborol-1(3H)-OlCAS NO: 174671-46-6Molecular Formula: C7H6BFO2Molecular Weight: 151.93Purity: 98% minSolubility: in DMSOStorage:

prudect name : AN-2690(Tavaborole) Synonyms: 5-Fluoro-2,1-Benzoxaborol-1(3H)-OlCAS NO: 174671-46-6Molecular Formula: C7H6BFO2Molecular Weight: 151.93Purity: 98% minSolubility: in DMSOStorage: -20oC 371935-79-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18497103

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Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 ¦ÌM, high selectivity over other key metabolic lipases.

prudect name : Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 ¦ÌM, high selectivity over other key metabolic lipases.Atglistatin Synonyms: CAS…

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A-803467 potently blocks recombinant human or rat NaV1.8 channels with IC50 of 8 nM and 45 nM, respectively, at a holding potential of -40 mV. At a resting state, A-803467 also potently blocks human NaV1.8 channels with IC50 of 79 nM. A-803467 blocks tetrodotoxin-resistant (TTX-R) currents in rat dorsal root ganglion neurons in a concentration-dependent manner with IC50 of 140 nM, more potently compared with both mexiletine and lamotrigine with IC50 of >30 ¦ÌM. A-803467 displays 300- to 1,000-fold higher selectivity for hNaV1.8 over hNaV1.2, hNaV1.3, hNaV1.5, and hNaV1.7 channels with IC50 of 7.38 ¦ÌM, 2.45 ¦ÌM, 7.34 ¦ÌM, and 6.74 ¦ÌM, respectively. A-803467 shows no significant activity against other channels and receptors expressed in peripheral sensory neurons including TRPV1, P2X2/3, CaV2.2 and KCNQ2/3 channels with IC50 >10 ¦ÌM. A-803467 also shows no or weak activity against a broad screening panel of cell-surface receptors, ion channels, and enzymes with IC50 of >2 ¦ÌM. A-803467 at 0.3 ¦ÌM but not 0.1 ¦ÌM significantly inhibits the generation of spontaneous and electrically evoked action potentials. [

prudect name : A-803467 potently blocks recombinant human or rat NaV1.8 channels with IC50 of 8 nM and 45 nM, respectively, at a holding potential of -40 mV. At a…

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prudect name : AN 2728Synonyms: CAS NO: 906673-24-3Molecular Formula: C14H10BNO3Molecular Weight: 251.05Purity: 98% minSolubility: in

prudect name : AN 2728 Synonyms: CAS NO: 906673-24-3Molecular Formula: C14H10BNO3Molecular Weight: 251.05Purity: 98% minSolubility: in DMSOStorage: -20oC 1233339-22-4 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18496947

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prudect name : ARRY-543Synonyms: ARRY-543CAS NO: 114629-86-8Molecular Formula: Molecular Weight: Purity: 98% minSolubility: In DMSOStorage:

prudect name : ARRY-543 Synonyms: ARRY-543CAS NO: 114629-86-8Molecular Formula: Molecular Weight: Purity: 98% minSolubility: In DMSOStorage: −20°C 1229208-44-9 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18496848

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An orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 uM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 uM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.

prudect name : An orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 uM) and the…

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ASP3026, a novel and selective inhibitor for the ALK kinase.

prudect name : ASP3026, a novel and selective inhibitor for the ALK kinase.ASP 3026 Synonyms: CAS NO: 1097917-15-1Molecular Formula: C29H40N8O3SMolecular Weight: 580.74Purity: 98% minSolubility: In DMSOStorage: −20°C 1222998-36-8 References PubMed…

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Poly(adenosine diphosphate-ribose) polymerase (PARP) is anenzyme that is involved in a specific kind of DNA repair called base-excision repair, which is used when there is an error in a strand of the DNA.IC50 (¦ÌM):PARP-1= 0.005,PARP-2= 0.001 , PF50=25.8.AZD2281(Olaparib) at 400 mg twice daily is well tolerated and highly active. The toxicity that was seen in BRCA1/BRCA2 carriers was similar to the previously reported toxicity in noncarriers

prudect name : Poly(adenosine diphosphate-ribose) polymerase (PARP) is anenzyme that is involved in a specific kind of DNA repair called base-excision repair, which is used when there is an error…

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