VD/VDR- vd-vdr

  • Role: administrator
  • Number of posts: 9343
  • Registration Date: September 2, 2015
  • Website:

Posts by VD/VDR- vd-vdr

prudect name : BeraprostSynonyms: CAS NO: 88430-50-6Molecular Formula: C24H30O5Molecular Weight: 398.49Purity: 99% minSolubility: Storage: −20°C

 June 21, 2017

prudect name : Beraprost Synonyms: CAS NO: 88430-50-6Molecular Formula: C24H30O5Molecular Weight: 398.49Purity: 99% minSolubility: Storage: −20°C 248281-84-7 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503622

📌
0💬 read more

Bafetinib (INNO-406) is an orally available, dual Abl/Lyn kinase inhibitor that is up to 55-times more potent than imatinib in Bcr-Abl cell lines. Numerous Bcr-Abl mutant proteins (not T315I) are sensitive to INNO-406 in vitro. INNO-406 demonstrates specific Src kinase activity against Lyn kinase.

prudect name : Bafetinib (INNO-406) is an orally available, dual Abl/Lyn kinase inhibitor that is up to 55-times more potent than imatinib in Bcr-Abl cell lines. Numerous Bcr-Abl mutant proteins…

📌
0💬 read more

BMS265246 inhibits the activity of CDK4/cycD with IC50 of 0.23 ¦ÌM and prevents A2780 Cytox with IC50 of 0.76 ¦ÌM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively. BMS265246 represents the most potent CDK/CDK2 selective analogue from this chemotype. A recent study shows that BMS-265246 inhibits cell proliferation with EC50 ranging from 0.293 ¦ÌM-0.492 ¦ÌM in HCT-116 cells. After treatment of BMS-265246, the dominant cell populations are G2-arrested cells having 4N DNA content, large round nuclei, and low DNA intensity.

prudect name : BMS265246 inhibits the activity of CDK4/cycD with IC50 of 0.23 ¦ÌM and prevents A2780 Cytox with IC50 of 0.76 ¦ÌM. BMS265246 which binds to CDK2 shows the…

📌
0💬 read more

prudect name : Bimatoprost isopropyl esterSynonyms: CAS NO: 130209-76-6Molecular Formula: C26H38O5Molecular Weight: 430.58Purity: 99% minSolubility:

prudect name : Bimatoprost isopropyl ester Synonyms: CAS NO: 130209-76-6Molecular Formula: C26H38O5Molecular Weight: 430.58Purity: 99% minSolubility: In DMSOStorage: −20°C 209216-23-9 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503525

📌
0💬 read more

prudect name : Bimatoprost acidSynonyms: Bimatoprost acidCAS NO: 38344-08-0Molecular Formula: C23H32O5Molecular Weight: 388.5Purity: 99% minSolubility:

prudect name : Bimatoprost acid Synonyms: Bimatoprost acidCAS NO: 38344-08-0Molecular Formula: C23H32O5Molecular Weight: 388.5Purity: 99% minSolubility: Storage: −20°C 745-65-3 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503457

📌
0💬 read more

prudect name : beta-Methyl vinyl phosphateSynonyms: MAPCAS NO: 90776-59-3Molecular Formula: C29H27N2O10PMolecular Weight: 594.52Purity: 98% minSolubility:

prudect name : beta-Methyl vinyl phosphate Synonyms: MAPCAS NO: 90776-59-3Molecular Formula: C29H27N2O10PMolecular Weight: 594.52Purity: 98% minSolubility: Storage: −20°C 1247819-59-5 References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18503415

📌
0💬 read more

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC, respectively. Meanwhile, in comparison to GSK3¦Â more than 100-fold selectivity observed for PDK1.

prudect name : BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC, respectively. Meanwhile, in…

📌
0💬 read more

BI 6727 is a highly potent Polo-like kinase inhibitor with an IC50 of 0 .87 nM BI 6727 has an EC50 of 11-37 nM on a panel of cancer cell lines and selective dihydropteridinone with distinct properties. BI 6727 has a pharmacokinetic profile favoring sustained exposure of tumor tissues with a high volume of distribution and a long terminal half-life in mice. BI 6727 has physicochemical and pharmacokinetic properties that allow in vivo testing of i.v. as well as oral formulations, adding flexibility to dosing schedules. BI 6727 shows marked antitumor activity in multiple cancer models, including a model of taxane-resistant colorectal cancer.

prudect name : BI 6727 is a highly potent Polo-like kinase inhibitor with an IC50 of 0 .87 nM BI 6727 has an EC50 of 11-37 nM on a panel…

📌
0💬 read more

BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively. HER1 expression has been shown in as much as 80% to 90% of colon and non¨Csmall- cell lung cancer. HER2 gene amplification and overexpression of the protein have been shown to occur in f30% of all breast cancer. BMS-599626 was highly selective when tested against a broad panel of diverse protein kinases. BMS-599626 abrogated HER1and HER2 signaling. BMS-599626 inhibited the proliferation of tumor cell lines that are dependent on these receptors, with IC50 in the range of 0.24 to 1 ¦ÌM.

prudect name : BMS-599626 is a highly selective pan-HERKinase inhibitor with IC50 of 20 and 30 nM for the inhibition of HER1and HER2, respectively. HER1 expression has been shown in…

📌
0💬 read more

BI 2536 is a small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1, derived from human, mouse and rat) (with IC50of 0.83 nM), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations.

prudect name : BI 2536 is a small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1, derived from human, mouse and rat)…

📌
0💬 read more
« Previous
1 … 839 840 841 842 843 … 935
Next »