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Tirasemtiv(CK 2017357) is a a small-molecule fast-skeletal-troponin activator, which is being developed as a potential treatment for diseases and conditions associated with aging, muscle weakness and wasting or neuromuscular dysfunction.

June 21, 2017

prudect name : Tirasemtiv(CK 2017357) is a a small-molecule fast-skeletal-troponin activator, which is being developed as a potential treatment for diseases and conditions associated with aging, muscle weakness and wasting…

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Ticagrelor(274693-27-5) (trade name Brilinta in the US, Brilique and Possia in the EU) is a platelet aggregation inhibitor produced by AstraZeneca. The drug was approved for use in the European Union by the European Commission on December 3, 2010. The drug was approved by the US Food and Drug Administration on July 20, 2011.

prudect name : Ticagrelor(274693-27-5) (trade name Brilinta in the US, Brilique and Possia in the EU) is a platelet aggregation inhibitor produced by AstraZeneca. The drug was approved for use…

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ARQ-197 has been shown to prevent HGF/c-met induced cellular responses in vitro. ARQ-197 possesses antitumor activity; inhibiting proliferation of A549, DBTRG and NCI-H441 cells with IC50 of 0.38, 0.45, 0.29 ¦ÌM. Treatment with ARQ-197 results in a decrease in phosphorylation of the MAPK signaling cascade and prevention of invasion and migration. In addition, ectopic expression of c-Met in NCI-H661, a cell line having no endogenous expression of c-Met, causes it to acquire an invasive phenotype that is also suppressed by ARQ-197. Although the addition of increasing concentrations of ARQ-197 does not significantly affect the Km of ATP, exposure of c-Met to 0.5 ¦ÌM ARQ-197 decreased the Vmax of c-Met by approximately 3-fold. The ability of ARQ-197 to decrease the Vmax without affecting the Km of ATP confirmed that ARQ-197 inhibits c-Met through a non¨CATP-competitive mechanism and may therefore account for its high degree of kinase selectivity. ARQ-197 prevents human recombinant c-Met with a calculated inhibitory constant Ki of approximately 355 nM. Although the highest concentration of ATP used is 200 ¦ÌM, the potency of ARQ-197 against c-Met is not reduced by using concentrations of ATP up to 1 mM. ARQ-197 blocks c-Met phosphorylation and downstream c-Met signaling pathways. ARQ-197 suppresses constitutive and ligand-mediated c-Met autophosphorylation and, by extension, c-Met activity, in turn leading to the inhibition of downstream c-Met effectors. ARQ-197 induction of caspase-dependent apoptosis is increased in c-Met¨Cexpressing human cancer cells including HT29, MKN-45, and MDA-MB-231 cells

prudect name : ARQ-197 has been shown to prevent HGF/c-met induced cellular responses in vitro. ARQ-197 possesses antitumor activity; inhibiting proliferation of A549, DBTRG and NCI-H441 cells with IC50 of…

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PD0332991£¨Palbociclib) Intermediates

prudect name : PD0332991£¨Palbociclib) Intermediatestert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Synonyms: CAS NO: 571188-59-5Molecular Formula: C14H22N4O2Molecular Weight: 278.35Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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TCS JNK 5a(JNK Inhibitor IX) is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38¦Á respectively); displays no significant activity at a range of other protein kinases including EGFR, ErbB2, cdk2,

prudect name : TCS JNK 5a(JNK Inhibitor IX) is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5,

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TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2.4/1.4 nM for BRAF V600E/c-RAF; > 60 fold selectivity over VEGFR.

prudect name : TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2.4/1.4 nM for BRAF V600E/c-RAF; > 60 fold selectivity over VEGFR.TAK 632;TAK-632;TAK632 Synonyms: CAS NO: 1228591-30-7Molecular…

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Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt. This agent is shown≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.

prudect name : Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2…

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prudect name : TOK-001Synonyms: VN124-1CAS NO: 851983-85-2Molecular Formula: C26H32N2OMolecular Weight: 388.55Purity: 98% minSolubility: In DMSOStorage:

prudect name : TOK-001 Synonyms: VN124-1CAS NO: 851983-85-2Molecular Formula: C26H32N2OMolecular Weight: 388.55Purity: 98% minSolubility: In DMSOStorage: -20°C web site: www.medchemexpress.com

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N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide

prudect name : N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamideTenovin-3 Synonyms: CAS NO: 1011301-27-1Molecular Formula: C18H21N3OSMolecular Weight: 327.444Purity: 98% minSolubility: in DMSOStorage: -20oC web site: www.medchemexpress.com

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TG100-115 is applied to anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). TG100-115 could reduce inflammation and mucin accumulation.

prudect name : TG100-115 is applied to anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). TG100-115 could reduce inflammation and mucin accumulation.TG100-115 Synonyms: CAS…

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